Judit Z Baffi
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Explore the profile of Judit Z Baffi including associated specialties, affiliations and a list of published articles.
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15
Citations
2329
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Recent Articles
1.
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, et al.
Signal Transduct Target Ther
. 2016 Feb;
1.
PMID: 26918197
Aberrant angiogenesis is implicated in diseases affecting nearly 10% of the world's population. The most widely used anti-angiogenic drug is bevacizumab, a humanized IgG1 monoclonal antibody that targets human VEGFA....
2.
Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler B, Ambati B, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(34):13781-6.
PMID: 22869729
Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in geographic atrophy...
3.
Deokule S, Baffi J, Guo H, Nazzaro M, Kaneko H
Acta Ophthalmol
. 2012 Jun;
90(5):e344-8.
PMID: 22676067
Purpose: To evaluate the safety profile of a brimonidine extended release intravitreal implant, in normotensive rabbit eyes. Methods: Devices were made from hollow poly-l-lactic acid (PLA) tubes and contained hundred...
4.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Tarallo V, Hirano Y, Gelfand B, Dridi S, Kerur N, Kim Y, et al.
Cell
. 2012 May;
149(4):847-59.
PMID: 22541070
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in...
5.
Kleinman M, Kaneko H, Cho W, Dridi S, Fowler B, Blandford A, et al.
Mol Ther
. 2011 Oct;
20(1):101-8.
PMID: 21988875
The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA) has propelled synthetic short-interfering RNAs (siRNAs) to the forefront of targeted pharmaceutical engineering. The first clinical trials utilized 21-nucleotide...
6.
Kaneko H, Dridi S, Tarallo V, Gelfand B, Fowler B, Cho W, et al.
Nature
. 2011 Feb;
471(7338):325-30.
PMID: 21297615
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced...
7.
Kleinman M, Baffi J, Ambati J
Ophthalmologica
. 2010 Aug;
224 Suppl 1:16-24.
PMID: 20714177
Retinal vascular disease is the most common cause of macular edema (ME). While there are several etiologies of vascular compromise and subsequent macular leakage, diabetic retinopathy is the most prevalent...
8.
Albuquerque R, Hayashi T, Cho W, Kleinman M, Dridi S, Takeda A, et al.
Nat Med
. 2009 Aug;
15(9):1023-30.
PMID: 19668192
Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have...
9.
Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al.
Nature
. 2009 Jun;
460(7252):225-30.
PMID: 19525930
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal...
10.
Cho W, Albuquerque R, Kleinman M, Tarallo V, Greco A, Nozaki M, et al.
Proc Natl Acad Sci U S A
. 2009 Apr;
106(17):7137-42.
PMID: 19359485
Neovascularization in response to tissue injury consists of the dual invasion of blood (hemangiogenesis) and lymphatic (lymphangiogenesis) vessels. We reported recently that 21-nt or longer small interfering RNAs (siRNAs) can...