Robert Steadman
Overview
Explore the profile of Robert Steadman including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
1952
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Recent Articles
1.
Moses R, Woods E, Dally J, Johns J, Knauper V, Boyle G, et al.
Biochem Pharmacol
. 2024 Nov;
230(Pt 2):116607.
PMID: 39489221
Epoxytiglianes are a novel class of diterpene esters. The prototype epoxytigliane, EBC-46 (tigilanol tiglate), is a potent anti-cancer agent in clinical development for local treatment of a range of human...
2.
Brown C, Pino-Chavez G, Zaidi A, Grigorieva I, Woods E, Steadman R, et al.
Int J Clin Exp Pathol
. 2024 May;
17(4):151-164.
PMID: 38716349
Objectives: Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are increasingly recognised as one disease continuum, rather than distinct entities, and are associated with a huge burden to healthcare...
3.
Moses R, Prescott T, Mas-Claret E, Steadman R, Moseley R, Sloan A
Biomolecules
. 2023 Mar;
13(3).
PMID: 36979379
Chronic, non-healing wounds represent a significant area of unmet medical need and are a growing problem for healthcare systems around the world. They affect the quality of life for patients...
4.
Hamilton K, Czajkowski D, Kong N, Tran T, Gustafson K, Pauly G, et al.
Antioxidants (Basel)
. 2022 Aug;
11(8).
PMID: 36009323
Bioactivity-guided fractionation was used to isolate two compounds, tomentosenol A () and torellianone A (), from a cerumen extract from . The anti-fibrotic activity of these compounds was examined using...
5.
Tai Y, Woods E, Dally J, Kong D, Steadman R, Moseley R, et al.
Biomolecules
. 2021 Aug;
11(8).
PMID: 34439762
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them...
6.
Woods E, Grigorieva I, Midgley A, Brown C, Lu Y, Phillips A, et al.
J Biol Chem
. 2021 Aug;
297(3):100987.
PMID: 34364871
Progressive fibrosis leads to loss of organ function and affects many organs as a result of excessive extracellular matrix production. The ubiquitous matrix polysaccharide hyaluronan (HA) is central to this...
7.
Moses R, Boyle G, Howard-Jones R, Errington R, Johns J, Gordon V, et al.
Biochem Pharmacol
. 2020 May;
178:114048.
PMID: 32446889
Epoxy-tiglianes are a novel class of diterpene esters. The prototype epoxy-tigliane, EBC-46 (tigilanol tiglate), possesses potent anti-cancer properties and is currently in clinical development as a local treatment for human...
8.
Midgley A, Woods E, Jenkins R, Brown C, Khalid U, Chavez R, et al.
Am J Pathol
. 2020 Mar;
190(6):1236-1255.
PMID: 32201263
Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive;...
9.
Wilson N, Steadman R, Muller I, Draman M, Aled Rees D, Taylor P, et al.
Int J Mol Sci
. 2019 Jun;
20(11).
PMID: 31151314
Hyaluronan (HA), an extra-cellular matrix glycosaminoglycan, may play a role in mesenchymal stem cell differentiation to fat but results using murine models and cell lines are conflicting. Our previous data,...
10.
Midgley A, Oltean S, Hascall V, Woods E, Steadman R, Phillips A, et al.
Sci Signal
. 2017 Nov;
10(506).
PMID: 29162741
The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis. The diversity of...