Robert C Cooksey
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Explore the profile of Robert C Cooksey including associated specialties, affiliations and a list of published articles.
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49
Citations
2569
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Recent Articles
1.
Nam H, Jones D, Cooksey R, Gao Y, Sink S, Cox J, et al.
Diabetes
. 2016 Mar;
65(6):1521-33.
PMID: 26993063
Hypoxia and iron both regulate metabolism through multiple mechanisms, including hypoxia-inducible transcription factors. The hypoxic effects on glucose disposal and glycolysis are well established, but less is known about the...
2.
Huang J, Simcox J, Creighton Mitchell T, Jones D, Cox J, Luo B, et al.
FASEB J
. 2013 Mar;
27(7):2845-54.
PMID: 23515442
Excess iron is associated with hepatic damage and diabetes in humans, although the detailed molecular mechanisms are not known. To investigate how iron regulates glucose homeostasis, we fed C57BL/6J male...
3.
Lee S, Jouihan H, Cooksey R, Jones D, Kim H, Winge D, et al.
Endocrinology
. 2013 Feb;
154(3):1029-38.
PMID: 23372018
Mitochondrial dysfunction is both a contributing mechanism and complication of diabetes, and oxidative stress contributes to that dysfunction. Mitochondrial manganese-superoxide dismutase (MnSOD) is a metalloenzyme that provides antioxidant protection. We...
4.
Gabrielsen J, Gao Y, Simcox J, Huang J, Thorup D, Jones D, et al.
J Clin Invest
. 2012 Sep;
122(10):3529-40.
PMID: 22996660
Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range serum...
5.
Boudina S, Sena S, Sloan C, Tebbi A, Han Y, ONeill B, et al.
Endocrinology
. 2012 Apr;
153(6):2677-88.
PMID: 22510273
This study sought to elucidate the relationship between skeletal muscle mitochondrial dysfunction, oxidative stress, and insulin resistance in two mouse models with differential susceptibility to diet-induced obesity. We examined the...
6.
Ge R, Simonson T, Cooksey R, Tanna U, Qin G, Huff C, et al.
Mol Genet Metab
. 2012 Apr;
106(2):244-7.
PMID: 22503288
Recent studies have identified genes involved in high-altitude adaptation in Tibetans. Genetic variants/haplotypes within regions containing three of these genes (EPAS1, EGLN1, and PPARA) are associated with relatively decreased hemoglobin...
7.
Soesanto Y, Luo B, Parker G, Jones D, Cooksey R, McClain D
J Biol Chem
. 2011 May;
286(29):26118-26.
PMID: 21622566
The hexosamine biosynthesis pathway (HBP) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine (O-GlcNAc). Numerous studies have demonstrated increased flux through this pathway contributes to the...
8.
Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel E, et al.
Diabetes
. 2010 Sep;
60(1):80-7.
PMID: 20876715
Objective: Excess tissue iron levels are a risk factor for diabetes, but the mechanisms underlying the association are incompletely understood. We previously published that mice and humans with a form...
9.
Cooksey R, McClain D
Amino Acids
. 2010 Jul;
40(3):841-6.
PMID: 20658157
Excess fatty acids and carbohydrates have both been implicated in the pathogenesis of type 2 diabetes, and both can reproduce essential features of the disease including insulin resistance and beta...
10.
Cooksey R, Jones D, Gabrielsen S, Huang J, Simcox J, Luo B, et al.
Am J Physiol Endocrinol Metab
. 2010 Apr;
298(6):E1236-43.
PMID: 20354157
Iron overload can cause insulin deficiency, but in some cases this may be insufficient to result in diabetes. We hypothesized that the protective effects of decreased iron would be more...