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E Dale Abel

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Articles 273
Citations 16876
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Perry A, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, et al.
Cell Rep Med . 2024 Dec; 5(12):101871. PMID: 39657669
Hepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating...
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Kumar A, Zhao Y, Xie L, Chadda R, Abraham N, Hong J, et al.
bioRxiv . 2024 Oct; PMID: 39386592
The lysosome integrates anabolic signalling and nutrient-sensing to regulate intracellular growth pathways. The leucine-rich repeat containing 8 (LRRC8) channel complex forms a lysosomal anion channel and regulates PI3K-AKT-mTOR signalling, skeletal...
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Streeter J, Persaud L, Gao J, Manika D, Fairman W, Garcia-Pena L, et al.
Front Endocrinol (Lausanne) . 2024 Oct; 15:1325286. PMID: 39381436
Introduction: Reducing Optic Atrophy 1 (OPA1) expression in skeletal muscle in male mice induces Activation Transcription Factor 4 (ATF4) and the integrated stress response (ISR). Additionally, skeletal muscle secretion of...
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Davenport A, Kessinger C, Pfeiffer R, Shah N, Xu R, Abel E, et al.
J Mol Cell Cardiol Plus . 2024 Sep; 9. PMID: 39323506
We have previously shown that the promoter drives Cre expression in a subset of male germ line cells in three independent mouse lines, including two transgenic lines and one knock-in...
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Pereira R, Abel E
EMBO J . 2024 Sep; 43(21):4807-4809. PMID: 39322755
No abstract available.
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Asadollahi E, Trevisiol A, Saab A, Looser Z, Dibaj P, Ebrahimi R, et al.
Nat Neurosci . 2024 Sep; 27(10):2046. PMID: 39289565
No abstract available.
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Zhang J, Sjoberg K, Gong S, Wang T, Li F, Kuo A, et al.
Cell Metab . 2024 Sep; 36(11):2383-2401.e9. PMID: 39270655
Endothelial cells (ECs) not only form passive blood conduits but actively contribute to nutrient transport and organ homeostasis. The role of ECs in glucose homeostasis is, however, poorly understood. Here,...
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Shi Q, Wang J, Malik H, Li X, Streeter J, Sharafuddin J, et al.
Circulation . 2024 Sep; 150(24):1966-1983. PMID: 39253856
Background: The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of (cIRS2-KO)...
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Asadollahi E, Trevisiol A, Saab A, Looser Z, Dibaj P, Ebrahimi R, et al.
Nat Neurosci . 2024 Sep; 27(10):1934-1944. PMID: 39251890
Brain function requires a constant supply of glucose. However, the brain has no known energy stores, except for glycogen granules in astrocytes. In the present study, we report that continuous...