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Sihem Boudina

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Articles 70
Citations 4827
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Recent Articles
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Werbner B, Stephens S, Stuart D, Hotchkiss T, Chapman J, Funai K, et al.
Physiol Rep . 2025 Jan; 12(18):e70072. PMID: 39776299
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in the context of hypertension and obesity and...
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Sciarretta F, Ninni A, Zaccaria F, Chiurchiu V, Bertola A, Karlinsey K, et al.
Cell Rep . 2024 Jul; 43(7):114447. PMID: 38963761
Obesity and type 2 diabetes cause a loss in brown adipose tissue (BAT) activity, but the molecular mechanisms that drive BAT cell remodeling remain largely unexplored. Using a multilayered approach,...
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Fennel Z, Bourrant P, Kurian A, Petrocelli J, de Hart N, Yee E, et al.
Aging Cell . 2024 Mar; 23(6):e14144. PMID: 38500398
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest...
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Ghosh R, Fatahian A, Rouzbehani O, Hathaway M, Mosleh T, Vinod V, et al.
Cardiovasc Res . 2024 Feb; 120(5):531-547. PMID: 38332738
Aims: Heart failure due to ischaemic heart disease (IHD) is a leading cause of mortality worldwide. A major contributing factor to IHD-induced cardiac damage is hypoxia. Sequestosome 1 (p62) is...
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Zhang Q, Li Z, Li Q, Trammell S, Schmidt M, Pires K, et al.
EMBO J . 2024 Jan; 43(3):362-390. PMID: 38212381
Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due to altered mitophagy and protein quality control. However, whether additional mechanisms are involved in the development...
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Jonnavithula A, Tandar M, Umar M, Orton S, Woodrum M, Mookherjee S, et al.
bioRxiv . 2024 Jan; PMID: 38168260
Objective: Pathologies including cardiovascular diseases, cancer, and neurological disorders are caused by the accumulation of misfolded / damaged proteins. Intracellular protein degradation mechanisms play a critical role in the clearance...
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Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, et al.
Circ Res . 2023 Dec; 134(2):143-161. PMID: 38156445
Background: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( [mitofusin-2] T/T) in the human mitochondrial fusion protein gene are associated with reduced platelet RNA expression and platelet counts. This...
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Sun B, Rouzbehani O, Kramer R, Ghosh R, Perelli R, Atkins S, et al.
Circ Heart Fail . 2023 Dec; 16(12):e010351. PMID: 38113297
Background: PRDM16 plays a role in myocardial development through TGF-β (transforming growth factor-beta) signaling. Recent evidence suggests that loss of PRDM16 expression is associated with cardiomyopathy development in mice, although...
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Kramer R, Fatahian A, Chan A, Mortenson J, Osher J, Sun B, et al.
Circ Genom Precis Med . 2023 Jul; 16(4):390-400. PMID: 37395136
Background: 1p36 deletion syndrome can predispose to pediatric-onset cardiomyopathy. Deletion breakpoints are variable and may delete the transcription factor . Early studies suggest that deletion of may underlie cardiomyopathy in...