Robert A Stavenger
Overview
Explore the profile of Robert A Stavenger including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
337
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Recent Articles
1.
Thorpe J, Wall I, Sinnamon R, Taylor A, Stavenger R
Acta Crystallogr F Struct Biol Commun
. 2020 Jan;
76(Pt 1):40-46.
PMID: 31929185
Direct soaking of protein crystals with small-molecule fragments grouped into complementary clusters is a useful technique when assessing the potential of a new crystal system to support structure-guided drug discovery....
2.
Thalji R, Raha K, Andreotti D, Checchia A, Cui H, Meneghelli G, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1407-1412.
PMID: 30962087
A series of DNA gyrase inhibitors were designed based on the X-ray structure of a parent thiophene scaffold with the objective to improve biochemical and whole-cell antibacterial activity, while reducing...
3.
Dumont E, Vergalli J, Pajovic J, Bhamidimarri S, Morante K, Wang J, et al.
Life Sci Alliance
. 2019 Jan;
2(1):e201800242.
PMID: 30620010
Small molecule accumulation in Gram-negative bacteria is a key challenge to discover novel antibiotics, because of their two membranes and efflux pumps expelling toxic molecules. An approach to overcome this...
4.
Acosta-Gutierrez S, Ferrara L, Pathania M, Masi M, Wang J, Bodrenko I, et al.
ACS Infect Dis
. 2018 Jul;
4(10):1487-1498.
PMID: 29962203
Small, hydrophilic molecules, including most important antibiotics in clinical use, cross the Gram-negative outer membrane through the water-filled channels provided by porins. We have determined the X-ray crystal structures of...
5.
Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, et al.
J Med Chem
. 2018 Mar;
61(8):3565-3581.
PMID: 29596745
In our quest for new antibiotics able to address the growing threat of multidrug resistant infections caused by Gram-negative bacteria, we have investigated an unprecedented series of non-quinolone bacterial topoisomerase...
6.
Germe T, Voros J, Jeannot F, Taillier T, Stavenger R, Bacque E, et al.
Nucleic Acids Res
. 2018 Mar;
46(8):4325.
PMID: 29596599
No abstract available.
7.
Germe T, Voros J, Jeannot F, Taillier T, Stavenger R, Bacque E, et al.
Nucleic Acids Res
. 2018 Mar;
46(8):4114-4128.
PMID: 29538767
Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies...
8.
Chan P, Germe T, Bax B, Huang J, Thalji R, Bacque E, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(22):E4492-E4500.
PMID: 28507124
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic...
9.
Concha N, Huang J, Bai X, Benowitz A, Brady P, Grady L, et al.
J Med Chem
. 2016 Jul;
59(15):7299-304.
PMID: 27379833
Undecaprenyl pyrophosphate synthase (UppS) is an essential enzyme in bacterial cell wall synthesis. Here we report the discovery of Staphylococcus aureus UppS inhibitors from an Encoded Library Technology screen and...
10.
Cinquin B, Maigre L, Pinet E, Chevalier J, Stavenger R, Mills S, et al.
Sci Rep
. 2015 Dec;
5:17968.
PMID: 26656111
Bacterial multidrug resistance is a significant health issue. A key challenge, particularly in Gram-negative antibacterial research, is to better understand membrane permeation of antibiotics in clinically relevant bacterial pathogens. Passing...