Thomas Germe
Overview
Explore the profile of Thomas Germe including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
216
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Recent Articles
1.
Orritt K, Feng L, Newell J, Sutton J, Grossman S, Germe T, et al.
RSC Med Chem
. 2022 Aug;
13(7):831-839.
PMID: 35919336
By 2050, it is predicted that antimicrobial resistance will be responsible for 10 million global deaths annually, more deaths than cancer, costing the world economy $100 trillion. Clearly, strategies to...
2.
Kolaric A, Germe T, Hrast M, Stevenson C, Lawson D, Burton N, et al.
Nat Commun
. 2021 Jan;
12(1):150.
PMID: 33420011
Novel bacterial type II topoisomerase inhibitors (NBTIs) stabilize single-strand DNA cleavage breaks by DNA gyrase but their exact mechanism of action has remained hypothetical until now. We have designed a...
3.
Bax B, Murshudov G, Maxwell A, Germe T
J Mol Biol
. 2019 Jul;
431(18):3427-3449.
PMID: 31301408
Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then resealing it. Bacterial type IIA topoisomerase...
4.
Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, et al.
J Med Chem
. 2018 Mar;
61(8):3565-3581.
PMID: 29596745
In our quest for new antibiotics able to address the growing threat of multidrug resistant infections caused by Gram-negative bacteria, we have investigated an unprecedented series of non-quinolone bacterial topoisomerase...
5.
Germe T, Voros J, Jeannot F, Taillier T, Stavenger R, Bacque E, et al.
Nucleic Acids Res
. 2018 Mar;
46(8):4325.
PMID: 29596599
No abstract available.
6.
Germe T, Voros J, Jeannot F, Taillier T, Stavenger R, Bacque E, et al.
Nucleic Acids Res
. 2018 Mar;
46(8):4114-4128.
PMID: 29538767
Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies...
7.
Chan P, Germe T, Bax B, Huang J, Thalji R, Bacque E, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(22):E4492-E4500.
PMID: 28507124
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic...
8.
Gaggioli V, Le Viet B, Germe T, Hyrien O
Nucleic Acids Res
. 2013 Jun;
41(15):7313-31.
PMID: 23757188
Sperm chromatin incubated in Xenopus egg extracts undergoes origin licensing and nuclear assembly before DNA replication. We found that depletion of DNA topoisomerase IIα (topo IIα), the sole topo II...
9.
Germe T, Miller K, Cooper J
EMBO J
. 2009 Aug;
28(18):2803-11.
PMID: 19680223
The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis. It is less clear, however, whether Top2 performs...
10.
Labit H, Perewoska I, Germe T, Hyrien O, Marheineke K
Nucleic Acids Res
. 2008 Sep;
36(17):5623-34.
PMID: 18765475
Replication origins in Xenopus egg extracts are located at apparently random sequences but are activated in clusters that fire at different times during S phase under the control of ATR/ATM...