Robert A Policastro
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Explore the profile of Robert A Policastro including associated specialties, affiliations and a list of published articles.
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14
Citations
197
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Recent Articles
1.
Fasteen T, Hernandez M, Policastro R, Sterrett M, Zenter G, Tennessen J
bioRxiv
. 2024 Sep;
PMID: 39314431
The Estrogen-Related Receptor (ERR) family of nuclear receptors (NRs) serve key roles in coordinating triglyceride (TAG) accumulation with juvenile growth and development. In both insects and mammals, ERR activity promotes...
2.
Wang H, Georgakopoulou A, Nizamis E, Mok K, Eluere R, Policastro R, et al.
Mol Ther Methods Clin Dev
. 2024 Sep;
32(3):101319.
PMID: 39282078
We developed an hematopoietic stem cell (HSC) gene therapy approach that does not require cell transplantation. To achieve therapeutically relevant numbers of corrected cells, we constructed HSC-tropic HDAd5/35++ vectors expressing...
3.
Mahmoudzadeh N, Heidarian Y, Tourigny J, Fitt A, Beebe K, Li H, et al.
Mol Metab
. 2024 Aug;
89:102013.
PMID: 39182840
Objectives: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell fate decisions. Loss of...
4.
Rai M, Li H, Policastro R, Zentner G, Nemkov T, DAlessandro A, et al.
bioRxiv
. 2024 Jun;
PMID: 38895259
larval growth requires efficient conversion of dietary nutrients into biomass. Lactate Dehydrogenase (Ldh) and Glycerol-3-phosphate dehydrogenase (Gpdh1) support larval biosynthetic metabolism by maintaining NAD/NADH redox balance and promoting glycolytic flux....
5.
Anand R, Layer J, Heja D, Hirose T, Lassiter G, Firl D, et al.
Nature
. 2023 Oct;
622(7982):393-401.
PMID: 37821590
Recent human decedent model studies and compassionate xenograft use have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must...
6.
Policastro R, Zentner G
Methods Mol Biol
. 2022 May;
2477:21-34.
PMID: 35524109
Transcription start site (TSS) usage is a critical factor in the regulation of gene expression. A number of methods for global TSS mapping have been developed, but barriers of expense,...
7.
Policastro R, Zentner G
Cell Rep Methods
. 2021 Oct;
1(5).
PMID: 34632443
Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform...
8.
Policastro R, McDonald D, Brendel V, Zentner G
NAR Genom Bioinform
. 2021 Jul;
3(2):lqab051.
PMID: 34250478
Heterogeneity in transcription initiation has important consequences for transcript stability and translation, and shifts in transcription start site (TSS) usage are prevalent in various developmental, metabolic, and disease contexts. Accordingly,...
9.
Miller S, Policastro R, Sriramkumar S, Lai T, Huntington T, Ladaika C, et al.
Cancer Res
. 2021 May;
81(14):3791-3805.
PMID: 34035083
Despite the connection of secretory cells, including goblet and enteroendocrine (EEC) cells, to distinct mucus-containing colorectal cancer histologic subtypes, their role in colorectal cancer progression has been underexplored. Here, our...
10.
Murach K, Peck B, Policastro R, Vechetti I, Van Pelt D, Dungan C, et al.
iScience
. 2021 May;
24(4):102372.
PMID: 33948557
Using muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal muscle...