Global Approaches for Profiling Transcription Initiation

Overview

Journal Cell Rep Methods

Specialty Cell Biology

Date 2021 Oct 11

PMID 34632443

Citations 8

Authors

Robert A Policastro

Gabriel E Zentner

Affiliations

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Abstract

Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including cancer. In this review, we discuss the breadth of techniques that have been used to globally profile TSSs and the resulting insights into gene regulation, as well as future prospects in this area of inquiry.

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