Angelo DAlessandro
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Explore the profile of Angelo DAlessandro including associated specialties, affiliations and a list of published articles.
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554
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13199
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Recent Articles
1.
Siciliano A, DAlessandro A, Matte A, Bisello G, Bertoldi M, Dzieciatkowska M, et al.
Blood Adv
. 2025 Mar;
PMID: 40085946
beta-thalassemia (beta-thal) is a worldwide hereditary red cell disorder characterized by severe chronic anemia. Recently, the pyruvate kinase (PK) activator mitapivat has been shown to improve anemia and ineffective erythropoiesis...
2.
DAlessandro A
Curr Opin Hematol
. 2025 Mar;
PMID: 40085132
Purpose Of Review: This review focuses on recent advances in the understanding of red blood cell (RBC) metabolism as a function of hypoxia and oxidant stress. In particular, we will...
3.
Haiman Z, Key A, DAlessandro A, Palsson B
PLoS Comput Biol
. 2025 Mar;
21(3):e1012109.
PMID: 40072998
Advancements with cost-effective, high-throughput omics technologies have had a transformative effect on both fundamental and translational research in the medical sciences. These advancements have facilitated a departure from the traditional...
4.
Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy M, Bruce J, et al.
J Clin Invest
. 2025 Mar;
PMID: 40067362
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologically-altered...
5.
Nemkov T, Isiksacan Z, William N, Senturk R, Boudreau L, Yarmush M, et al.
Res Sq
. 2025 Mar;
PMID: 40060052
Red blood cell (RBC) transfusion, a life-saving intervention, is limited by reduced RBC potency over time. Cold storage at + 4°C for up to 42 days can reduce transfusion efficacy...
6.
Lesbats J, Brillac A, Reisz J, Mukherjee P, Lhuissier C, Fernandez-Monreal M, et al.
Nature
. 2025 Feb;
PMID: 40011782
Macrophages specialize in phagocytosis, a cellular process that eliminates extracellular matter, including microorganisms, through internalization and degradation. Despite the critical role of phagocytosis during bacterial infection, the fate of phagocytosed...
7.
Trujillo M, Jennings E, Farrera D, Kitamura N, Anderson C, Gehrke S, et al.
Chembiochem
. 2025 Feb;
:e202401086.
PMID: 39988553
Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in de novo Ser biosynthesis. Numerous metabolic pathways rely on Ser as a precursor, most notably one-carbon metabolism, glutathione biosynthesis, and de novo...
8.
Miglio A, Di Tommaso M, Rocconi F, Reisz J, DAlessandro A
Blood Transfus
. 2025 Feb;
PMID: 39950860
Background: Blood transfusion is a life-saving intervention for many species of veterinary interest, including sheep. Despite extensive research on the impact of refrigerated storage of packed red blood cells (pRBC)...
9.
Rana N, Lisk C, Cendali F, Lucero M, Grier A, Setua S, et al.
J Proteome Res
. 2025 Feb;
24(3):1306-1316.
PMID: 39947632
Sickle cell disease and β-Thalassemia are two of the most prevalent hemoglobinopathies worldwide. Both occur due to genetic mutations within the HBB gene and are characterized by red blood cell...
10.
Heidarian Y, Fasteen T, Mungcal L, Buddika K, Mahmoudzadeh N, Nemkov T, et al.
Mol Metab
. 2025 Feb;
93:102106.
PMID: 39894213
Objectives: The rapid growth that occurs during Drosophila larval development requires a dramatic rewiring of central carbon metabolism to support biosynthesis. Larvae achieve this metabolic state, in part, by coordinately...