Shruthi Sriramkumar
Overview
Explore the profile of Shruthi Sriramkumar including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
270
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Recent Articles
1.
Sriramkumar S, Metcalfe T, Lai T, Zong X, Fang F, OHagan H, et al.
PLoS One
. 2022 Aug;
17(8):e0271584.
PMID: 35921335
Ovarian cancer (OC) is a lethal gynecological malignancy with a five-year survival rate of only 46%. Development of resistance to platinum-based chemotherapy is a common cause of high mortality rates...
2.
Muralikrishnan V, Fang F, Given T, Podicheti R, Chtcherbinine M, Metcalfe T, et al.
Cancers (Basel)
. 2022 Jul;
14(14).
PMID: 35884498
Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and the development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible...
3.
Sriramkumar S, Sood R, Huntington T, Ghobashi A, Vuong T, Metcalfe T, et al.
J Transl Med
. 2022 Jun;
20(1):246.
PMID: 35641987
Background: Platinum based agents-cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant...
4.
Miller S, Policastro R, Sriramkumar S, Lai T, Huntington T, Ladaika C, et al.
Cancer Res
. 2021 May;
81(14):3791-3805.
PMID: 34035083
Despite the connection of secretory cells, including goblet and enteroendocrine (EEC) cells, to distinct mucus-containing colorectal cancer histologic subtypes, their role in colorectal cancer progression has been underexplored. Here, our...
5.
DeStefano Shields C, White J, Chung L, Wenzel A, Hicks J, Tam A, et al.
Cancer Discov
. 2021 Feb;
11(7):1792-1807.
PMID: 33632774
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in are associated...
6.
Sriramkumar S, Matthews T, Ghobashi A, Miller S, VanderVere-Carozza P, Pawelczak K, et al.
Mol Cancer Res
. 2020 Aug;
18(11):1699-1710.
PMID: 32801161
Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER),...
7.
Miller S, Policastro R, Savant S, Sriramkumar S, Ding N, Lu X, et al.
Mol Cancer Res
. 2019 Nov;
18(2):264-277.
PMID: 31704733
Activation of the epithelial-to-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers contain many genetic and epigenetic alterations that can contribute to EMT....
8.
Savant S, Sriramkumar S, OHagan H
Cancers (Basel)
. 2018 Aug;
10(8).
PMID: 30061485
Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC....
9.
Maiuri A, Peng M, Podicheti R, Sriramkumar S, Kamplain C, Rusch D, et al.
Cancer Res
. 2017 May;
77(13):3467-3478.
PMID: 28522752
Aberrant silencing of genes by DNA methylation contributes to cancer, yet how this process is initiated remains unclear. Using a murine model of inflammation-induced tumorigenesis, we tested the hypothesis that...