Robert A Coleman
Overview
Explore the profile of Robert A Coleman including associated specialties, affiliations and a list of published articles.
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39
Citations
901
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Recent Articles
11.
Woodward D, Wang J, Coleman R, Woodrooffe A, Clark K, Stamer W, et al.
J Ocul Pharmacol Ther
. 2019 Apr;
35(5):265-277.
PMID: 31025909
Two features define the future of glaucoma therapeutics: (1) greatly improved ocular hypotensive efficacy and (2) a delivery method that improves patient convenience and compliance. A highly efficacious and extraordinarily...
12.
Carvajal L, Ben Neriah D, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, et al.
Sci Transl Med
. 2018 Apr;
10(436).
PMID: 29643228
The tumor suppressor p53 is often inactivated via its interaction with endogenous inhibitors mouse double minute 4 homolog (MDM4 or MDMX) or mouse double minute 2 homolog (MDM2), which are...
13.
Liu W, Coleman R, Singh S
Transcription
. 2017 Aug;
9(2):102-107.
PMID: 28795863
To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that...
14.
Coleman R, Liang C, Patel R, Ali S, Mukherjee J
Mol Imaging
. 2017 Jun;
16:1536012117704557.
PMID: 28654383
Objective: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid...
15.
Singh S, Qiao Z, Song L, Jani V, Rice W, Eng E, et al.
Genes Dev
. 2016 Dec;
30(22):2527-2537.
PMID: 27920087
The master tumor suppressor p53 activates transcription in response to various cellular stresses in part by facilitating recruitment of the transcription machinery to DNA. Recent studies have documented a direct...
16.
Donati-Bourne J, Roberts H, Rajjoub Y, Coleman R
Rev Urol
. 2016 May;
17(2):69-77.
PMID: 27222642
Transplantation is a viable treatment option for failure of most major organs. Within urology, transplantation of the kidney and ureter are well documented; however, evidence supporting transplantation of other urologic...
17.
Coleman R, Liu Z, Darzacq X, Tjian R, Singer R, Lionnet T
Cold Spring Harb Symp Quant Biol
. 2016 Jan;
80:1-8.
PMID: 26763984
Transcription, the first step of gene expression, is exquisitely regulated in higher eukaryotes to ensure correct development and homeostasis. Traditional biochemical, genetic, and genomic approaches have proved successful at identifying...
18.
19.
Coleman R
Altern Lab Anim
. 2015 Jan;
42(6):357-66.
PMID: 25635644
The Three Rs was a concept originally conceived as a means of reducing the suffering of laboratory animals that are used largely in identifying any potential safety issues with chemicals...
20.
Kaur J, Khararjian A, Coleman R, Constantinescu C, Pan M, Mukherjee J
Nucl Med Biol
. 2014 Sep;
41(10):841-7.
PMID: 25199843
Objectives: The spinal cord is known to be innervated with dopaminergic cells with catecholaminergic projections arising from the medulla and pons and dopaminergic transmission in the spinal cord is vital...