Cristian C Constantinescu
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Explore the profile of Cristian C Constantinescu including associated specialties, affiliations and a list of published articles.
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32
Citations
517
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Recent Articles
1.
Kielbasa W, Goldsmith P, Donnelly K, Nuthall H, Shcherbinin S, Fleisher A, et al.
Alzheimers Dement (N Y)
. 2025 Jan;
10(4):e70020.
PMID: 39748851
Introduction: The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies....
2.
Kaittanis C, Teceno T, Knight A, Petibon Y, Sandoval P, Cohen L, et al.
Mol Ther
. 2024 Nov;
PMID: 39563031
Longitudinal, non-invasive, in vivo monitoring of therapeutic gene expression is an unmet need for gene therapy (GT). Positron emission tomography (PET) radiotracers designed to bind to therapeutic proteins may provide...
3.
Piel I, Constantinescu C, de la Puente Bethencourt D, Bonsall D, Rabiner E, Zasadny K, et al.
J Cereb Blood Flow Metab
. 2024 Oct;
:271678X241291949.
PMID: 39479946
This paper describes the preclinical validation of the radioligand [C]ORM-13070 and its tritiated analog for addressing selectivity and occupancy of the selective alpha-2C adrenergic receptor (αR) antagonist BAY 292 in...
4.
Constantinescu C, Brown T, Wang S, Yin W, Barret O, Jennings D, et al.
J Nucl Med
. 2023 Sep;
64(12):1972-1979.
PMID: 37770111
This series of studies characterized [F]T-008, a PET radiotracer for imaging cholesterol 24-hydroxylase (CH24H), in healthy volunteers (ClinicalTrials.gov identifier NCT02497235). Assessments included radiation dosimetry, kinetic modeling, test-retest variability (TRT) evaluation,...
5.
Ikeda S, Kajita Y, Miyamoto M, Matsumiya K, Ishii T, Nishi T, et al.
Eur J Med Chem
. 2022 Jul;
240:114612.
PMID: 35863274
Cholesterol 24-hydroxylase (CH24H, CYP46A1) is a cytochrome P450 family enzyme that maintains the homeostasis of brain cholesterol. Soticlestat, a potent and selective CH24H inhibitor, is in development as a therapeutic...
6.
Koike T, Constantinescu C, Ikeda S, Nishi T, Sunahara E, Miyamoto M, et al.
Eur J Nucl Med Mol Imaging
. 2021 Oct;
49(4):1148-1156.
PMID: 34651220
Purpose: Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being...
7.
Hattori Y, Matsuda S, Baba R, Matsumiya K, Iwasaki S, Constantinescu C, et al.
J Med Chem
. 2021 Mar;
64(7):3780-3793.
PMID: 33729758
Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide...
8.
Barret O, Zhang L, Alagille D, Constantinescu C, Sandiego C, Papin C, et al.
J Nucl Med
. 2021 Feb;
62(9):1307-1313.
PMID: 33579806
Non-catechol-based high-affinity selective dopamine D receptor (D1R) agonists were recently described, and candidate PET ligands were selected on the basis of favorable properties. The objective of this study was to...
9.
Lew R, Constantinescu C, Holden D, Carson R, Carroll V, Galluppi G, et al.
Psychopharmacology (Berl)
. 2020 Aug;
237(11):3435-3446.
PMID: 32813030
Rationale: Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential...
10.
Schmidt M, Janssens L, Moechars D, Rombouts F, Timmers M, Barret O, et al.
Eur J Nucl Med Mol Imaging
. 2020 Jun;
47(13):3176-3185.
PMID: 32535652
Purpose: The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer's disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative...