Richard K Gordon
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Explore the profile of Richard K Gordon including associated specialties, affiliations and a list of published articles.
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37
Citations
202
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Recent Articles
1.
Bhattacharjee A, Marek E, Le H, Ratcliffe R, DeMar J, Pervitsky D, et al.
Eur J Med Chem
. 2014 Dec;
90:209-20.
PMID: 25461321
Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through...
2.
Morasch K, Aaron C, Moon J, Gordon R
Physiol Behav
. 2014 Dec;
138:165-72.
PMID: 25455867
Introduction: Based on common pharmacodynamic mechanisms, recent efforts to develop second generation alternatives for organophosphate (OP) prophylaxis have expanded to include cholinesterase (ChE) inhibiting compounds traditionally approved for use in...
3.
Bhattacharjee A, Pomponio J, Evans S, Pervitsky D, Gordon R
Bioorg Med Chem
. 2013 Mar;
21(9):2651-62.
PMID: 23523385
Muscarinic acetylcholine receptors (mAChRs) have five known subtypes which are widely distributed in both the peripheral and central nervous system for regulation of a variety of cholinergic functions. Atropine is...
4.
Bhattacharjee A, Kuca K, Musilek K, Gordon R
Med Chem
. 2012 Mar;
8(2):230-45.
PMID: 22385173
A comparative analysis of stereo-electronic properties of five cholinesterase reactivators (pralidoxime (2- PAM), trimedoxime, obidoxime, HI-6, and HLo-7) and six "K-oximes" was performed to assess their roles in reactivating OP-inhibited...
5.
Bhattacharjee A, Marek E, Le H, Gordon R
Eur J Med Chem
. 2012 Feb;
49:229-38.
PMID: 22309910
We earlier reported an in silico pharmacophore model for reactivation of oximes to tabun-inhibited AChE. Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a...
6.
Khan F, Campbell A, Hoyt B, Herdman C, Ku T, Thangavelu S, et al.
Life Sci
. 2011 Oct;
89(25-26):911-7.
PMID: 21989207
Aims: Due to pralidoxime chloride's (2-PAM) positive charge, it's penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor....
7.
DeMar J, Clarkson E, Ratcliffe R, Campbell A, Thangavelu S, Herdman C, et al.
Chem Biol Interact
. 2010 Feb;
187(1-3):191-8.
PMID: 20156430
Novel therapeutics to overcome the toxic effects of organophosphorus (OP) chemical agents are needed due to the documented use of OPs in warfare (e.g. 1980-1988 Iran/Iraq war) and terrorism (e.g....
8.
Haigh J, Adler M, Apland J, Deshpande S, Barham C, Desmond P, et al.
Chem Biol Interact
. 2010 Feb;
187(1-3):416-20.
PMID: 20144889
Pyridostigmine bromide (PB) was approved by the U.S. Food and Drug Administration (FDA) in 2003 as a pretreatment in humans against the lethal effects of the irreversible nerve agent soman...
9.
Bhattacharjee A, Kuca K, Musilek K, Gordon R
Chem Res Toxicol
. 2009 Dec;
23(1):26-36.
PMID: 20028185
Organophosphorus (OP) nerve agents that inhibit acetylcholinesterase (AChE; EC 3.1.1.7) function in the nervous system, causing acute intoxication. If untreated, death can result. Inhibited AChE can be reactivated by oximes,...
10.
Nambiar M, Wright B, Rezk P, Smith K, Gordon R, Moran T, et al.
Toxicol Mech Methods
. 2009 Dec;
16(6):295-306.
PMID: 20021028
Respiratory disturbances due to chemical warfare nerve agents (CWNAs) are the starting point of mass casualty and the primary cause of death by these weapons of terror and mass destruction....