Peter E Rezk
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Explore the profile of Peter E Rezk including associated specialties, affiliations and a list of published articles.
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10
Citations
40
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Recent Articles
1.
Mata D, Sabnekar P, Watson C, Rezk P, Chilukuri N
Chem Biol Interact
. 2016 Apr;
259(Pt B):233-241.
PMID: 27083144
We evaluated the ability of evolved paraoxonase-1 (PON1) to afford broad spectrum protection against G-type nerve agents when produced in mammalian cells via an adenovirus expression system. The PON1 variants...
2.
Mata D, Rezk P, Sabnekar P, Cerasoli D, Chilukuri N
J Pharmacol Exp Ther
. 2014 Apr;
349(3):549-58.
PMID: 24706983
We investigated the ability of the engineered paraoxonase-1 variants G3C9, VII-D11, I-F11, and VII-D2 to afford protection against paraoxon intoxication. Paraoxon is the toxic metabolite of parathion, a common pesticide...
3.
Rezk P, Zdenka P, Sabnekar P, Kajih T, Mata D, Wrobel C, et al.
Drug Chem Toxicol
. 2014 Mar;
38(1):37-43.
PMID: 24641262
In this study, we determined the ability of recombinant human liver prolidase to hydrolyze nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus...
4.
Che M, Chanda S, Song J, Doctor B, Rezk P, Sabnekar P, et al.
Toxicol Mech Methods
. 2011 Jun;
21(6):463-72.
PMID: 21651338
Sarin is a volatile nerve agent that has been used in the Tokyo subway attack. Inhalation is predicted to be the major route of exposure if sarin is used in...
5.
Nambiar M, Wright B, Rezk P, Smith K, Gordon R, Moran T, et al.
Toxicol Mech Methods
. 2009 Dec;
16(6):295-306.
PMID: 20021028
Respiratory disturbances due to chemical warfare nerve agents (CWNAs) are the starting point of mass casualty and the primary cause of death by these weapons of terror and mass destruction....
6.
Rezk P, Graham J, Moran T, Gordon R, Sciuto A, Doctor B, et al.
Inhal Toxicol
. 2007 Mar;
19(3):291-302.
PMID: 17365032
Exposure to a chemical warfare nerve agent (CWNA) leads to severe respiratory distress, respiratory failure, or death if not treated. We investigated the toxic effects of nerve agent VX on...
7.
Nambiar M, Gordon R, Rezk P, Katos A, Wajda N, Moran T, et al.
Toxicol Appl Pharmacol
. 2006 Dec;
219(2-3):142-50.
PMID: 17188727
To develop therapeutics against lung injury and respiratory toxicity following nerve agent VX exposure, we evaluated the protective efficacy of a number of potential pulmonary therapeutics. Guinea pigs were exposed...
8.
Tetz L, Rezk P, Ratcliffe R, Gordon R, Steele K, Nambiar M
Toxicol Ind Health
. 2006 Aug;
22(6):255-66.
PMID: 16924957
We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1.6-2.0 x LD50 soman exposure, to analyse the molecular mechanism of neuronal damage and to screen effective neuroprotectants...
9.
Graham J, Wright B, Rezk P, Gordon R, Sciuto A, Nambiar M
Inhal Toxicol
. 2006 Apr;
18(7):493-500.
PMID: 16603480
Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed...
10.
Wright B, Rezk P, Graham J, Steele K, Gordon R, Sciuto A, et al.
Inhal Toxicol
. 2006 Mar;
18(6):437-48.
PMID: 16556583
A microinstillation technique of inhalation exposure was utilized to assess lung injury following chemical warfare nerve agent VX [methylphosphonothioic acid S-(2-[bis(1-methylethyl)amino]ethyl) O-ethyl ester] exposure in guinea pigs. Animals were anesthetized...