Richard K Gordon
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Explore the profile of Richard K Gordon including associated specialties, affiliations and a list of published articles.
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37
Citations
202
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Recent Articles
11.
Conti M, Che M, Boylan M, Sciuto A, Gordon R, Nambiar M
Int J Toxicol
. 2009 Oct;
28(5):436-47.
PMID: 19815847
This study investigates the toxic effects of sarin on respiratory dynamics following microinstillation inhalation exposure in guinea pigs. Animals are exposed to sarin for 4 minutes, and respiratory functions are...
12.
Shi X, Curran J, Liao Z, Gordon R
J Cell Biochem
. 2009 Aug;
108(3):660-7.
PMID: 19681043
BoNT/B light chain is a zinc-dependent endopeptidase. After entering its target, the neuronal cell, BoNT/B is responsible for synaptobrevin-2 (VAMP-2) cleavage. This results in reduced neurotransmitter (acetylcholine) release from synaptic...
13.
Che M, Conti M, Chanda S, Boylan M, Sabnekar P, Rezk P, et al.
Toxicol Appl Pharmacol
. 2009 Jun;
239(3):251-7.
PMID: 19523969
We evaluated the protective efficacy of nasal atropine methyl bromide (AMB) which does not cross the blood-brain barrier against sarin inhalation exposure. Age and weight matched male guinea pigs were...
14.
Shi X, Garcia G, Neill R, Gordon R
J Cell Biochem
. 2009 Jun;
107(5):1021-30.
PMID: 19492407
The light chain (LC) of botulinum neurotoxin B (BoNT/B) is unable to enter target neuronal cells by itself. It is brought into the cell in association with the BoNT/B heavy...
15.
Bhattacharjee A, Gordon J, Marek E, Campbell A, Gordon R
Bioorg Med Chem
. 2009 May;
17(11):3999-4012.
PMID: 19409797
Muscarinic acetylcholine receptors (mAChRs) consisting of five known subtypes, are widely distributed in both central and peripheral nervous systems for regulation of a variety of critical functions. The present theoretical...
16.
Katos A, Conti M, Moran T, Chon T, Gordon R, Sciuto A, et al.
Inhal Toxicol
. 2009 Feb;
21(7):1-10.
PMID: 19229713
We investigated the toxic effects of the chemical warfare nerve agent (CWNA) soman (GD) on the respiratory dynamics of guinea pigs following microinstillation inhalation exposure. Male Hartley guinea pigs were...
17.
Che M, Conti M, Boylan M, Sciuto A, Gordon R, Nambiar M
Inhal Toxicol
. 2008 Jul;
20(9):821-8.
PMID: 18645722
We determined acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition in the bronchoalveolar lavage fluid (BALF) following inhalation exposure to chemical threat nerve agent (CTNA) sarin. Age- and weight-matched male guinea pigs...
18.
Coleman B, Ratcliffe R, Oguntayo S, Shi X, Doctor B, Gordon R, et al.
Chem Biol Interact
. 2008 Jul;
175(1-3):387-95.
PMID: 18588864
The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release...
19.
Haigh J, Johnston S, Peppernay A, Mattern P, Garcia G, Doctor B, et al.
Chem Biol Interact
. 2008 Jun;
175(1-3):380-6.
PMID: 18572153
As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an...
20.
Haigh J, Lefkowitz L, Capacio B, Doctor B, Gordon R
Chem Biol Interact
. 2008 Jun;
175(1-3):417-20.
PMID: 18555983
Red blood cell AChE (RBC-AChE) and plasma BChE can be used as sensitive biomarkers to detect exposure to OP nerve agents, pesticides, and cholinergic drugs. In a comparative study, RBC-AChE...