Richard G Hibbert
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Explore the profile of Richard G Hibbert including associated specialties, affiliations and a list of published articles.
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17
Citations
598
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Recent Articles
1.
Hiemstra I, Santegoets K, Janmaat M, De Goeij B, Ten Hagen W, van Dooremalen S, et al.
EBioMedicine
. 2023 Jun;
93:104663.
PMID: 37379657
Background: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon...
2.
van der Wulp W, Gram A, Bleijlevens B, Hagedoorn R, Araman C, Kim R, et al.
Front Immunol
. 2023 Jun;
14:1183914.
PMID: 37261346
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to...
3.
Overdijk M, Strumane K, Beurskens F, Ortiz Buijsse A, Vermot-Desroches C, Vuillermoz B, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):2126-2138.
PMID: 32847982
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific...
4.
Hayashi A, Giakoumakis N, Heidebrecht T, Ishii T, Panagopoulos A, Caillat C, et al.
Life Sci Alliance
. 2019 Jan;
1(6):e201800238.
PMID: 30623174
The CRL4 ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of substrate degrons on...
5.
Yuan D, Keeble A, Hibbert R, Fabiane S, Gould H, McDonnell J, et al.
J Biol Chem
. 2013 Jun;
288(30):21667-77.
PMID: 23775083
Immunoglobulin E (IgE) antibodies play a fundamental role in allergic disease and are a target for therapeutic intervention. IgE functions principally through two receptors, FcεRI and CD23 (FcεRII). Minute amounts...
6.
Hibbert R, Sixma T
J Biol Chem
. 2012 Sep;
287(46):39216-23.
PMID: 22989887
Ubiquitin conjugation provides a crucial signaling role in hundreds of cellular pathways; however, a structural understanding of ubiquitinated substrates is lacking. One important substrate is monoubiquitinated PCNA (PCNA-Ub), which signals...
7.
Borthakur S, Hibbert R, Pang M, Yahya N, Bax H, Kao M, et al.
J Biol Chem
. 2012 Jul;
287(37):31457-61.
PMID: 22815482
IgE, the antibody that mediates allergic responses, acts as part of a self-regulating protein network. Its unique effector functions are controlled through interactions of its Fc region with two cellular...
8.
Inagaki A, Sleddens-Linkels E, van Cappellen W, Hibbert R, Sixma T, Hoeijmakers J, et al.
PLoS One
. 2011 Aug;
6(8):e23155.
PMID: 21858012
RAD18 is an ubiquitin ligase involved in replicative damage bypass and DNA double-strand break (DSB) repair processes. We found that RPA is required for the dynamic pattern of RAD18 localization...
9.
Huang A, Hibbert R, de Jong R, Das D, Sixma T, Boelens R
J Mol Biol
. 2011 May;
410(3):424-35.
PMID: 21549715
The human ubiquitin-conjugating enzyme Rad6 (E2), with ubiquitin ligase enzyme Rad18 (RING E3), monoubiquitinates proliferating cell nuclear antigen at stalled replication forks in DNA translesion synthesis. Here, we determine the...
10.
Luna-Vargas M, Christodoulou E, Alfieri A, van Dijk W, Stadnik M, Hibbert R, et al.
J Struct Biol
. 2011 Apr;
175(2):113-9.
PMID: 21453775
High-throughput methods to produce a large number of soluble recombinant protein variants are particularly important in the process of determining the three-dimensional structure of proteins and their complexes. Here, we...