Andrew J Beavil
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Explore the profile of Andrew J Beavil including associated specialties, affiliations and a list of published articles.
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46
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1207
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Recent Articles
1.
Davies A, Bui T, Pacheco-Gomez R, Vester S, Beavil A, Gould H, et al.
Proteins
. 2024 Nov;
93(4):786-800.
PMID: 39582378
Of the five human antibody isotypes, the function of IgD is the least well-understood, although various studies point to a role for IgD in mucosal immunity. IgD is also the...
2.
Calvert R, Nyamboya R, Beavil A, Sutton B
Front Immunol
. 2024 Oct;
15:1389494.
PMID: 39445016
Introduction: Antibody Fc regions harbour the binding sites for receptors that mediate effector functions following antigen engagement by the Fab regions. An extended "hinge" region in IgG allows flexibility between...
3.
Vester S, Davies A, Beavil R, Sandhar B, Beavil A, Gould H, et al.
Antibodies (Basel)
. 2023 Nov;
12(4).
PMID: 37987253
We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In...
4.
Davies A, Beavil R, Barbolov M, Sandhar B, Gould H, Beavil A, et al.
Mol Immunol
. 2023 Jun;
159:28-37.
PMID: 37267832
Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the Fab region of IgD, based on four different...
5.
Chauhan J, Grandits M, Palhares L, Mele S, Nakamura M, Lopez-Abente J, et al.
Nat Commun
. 2023 May;
14(1):2192.
PMID: 37185332
Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effective...
6.
Evans S, Al-Hazeem M, Mann D, Smetacek N, Beavil A, Sun Y, et al.
Structure
. 2023 Apr;
31(6):677-688.e4.
PMID: 37015227
Carboxysomes are proteinaceous bacterial microcompartments that sequester the key enzymes for carbon fixation in cyanobacteria and some proteobacteria. They consist of a virus-like icosahedral shell, encapsulating several enzymes, including ribulose...
7.
Corogeanu D, Zaki K, Beavil A, Arnold J, Diebold S
PLoS One
. 2023 Mar;
18(3):e0282831.
PMID: 36913398
Imiquimod, a Toll-like receptor 7 (TLR7) agonist is routinely used for topical administration in basal cell carcinoma and stage zero melanoma. Similarly, the TLR agonist Bacillus Calmette-Guérin is used for...
8.
Ilkow V, Davies A, Dhaliwal B, Beavil A, Sutton B, McDonnell J
FEBS Open Bio
. 2021 Jun;
11(7):1827-1840.
PMID: 34075727
Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses. IgE's interaction with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor,...
9.
Vester S, Beavil R, Lynham S, Beavil A, Cunninghame Graham D, McDonnell J, et al.
J Biol Chem
. 2021 Mar;
296:100513.
PMID: 33676896
The C1q and TNF related 4 (C1QTNF4) protein is a structurally unique member of the C1QTNF family, a family of secreted proteins that have structural homology with both complement C1q...
10.
Time-Resolved Fluorescence Anisotropy and Molecular Dynamics Analysis of a Novel GFP Homo-FRET Dimer
Teijeiro-Gonzalez Y, Crnjar A, Beavil A, Beavil R, Nedbal J, Le Marois A, et al.
Biophys J
. 2020 Dec;
120(2):254-269.
PMID: 33345902
Förster resonance energy transfer (FRET) is a powerful tool to investigate the interaction between proteins in living cells. Fluorescence proteins, such as the green fluorescent protein (GFP) and its derivatives,...