Brian J Sutton
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Explore the profile of Brian J Sutton including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Davies A, Trentham D, Sutton B, Brown P
Biochem Biophys Res Commun
. 2025 Mar;
755:151539.
PMID: 40054337
Phosphinothricin inhibits plant glutamine synthetase and is used as a herbicide. Streptomyces hygroscopicus and Streptomyces viridochromogenes, which produce phosphinothricin naturally, encode acetyltransferases that confer phosphinothricin resistance. In the Pseudomonas genome...
2.
Davies A, Bui T, Pacheco-Gomez R, Vester S, Beavil A, Gould H, et al.
Proteins
. 2024 Nov;
93(4):786-800.
PMID: 39582378
Of the five human antibody isotypes, the function of IgD is the least well-understood, although various studies point to a role for IgD in mucosal immunity. IgD is also the...
3.
Calvert R, Nyamboya R, Beavil A, Sutton B
Front Immunol
. 2024 Oct;
15:1389494.
PMID: 39445016
Introduction: Antibody Fc regions harbour the binding sites for receptors that mediate effector functions following antigen engagement by the Fab regions. An extended "hinge" region in IgG allows flexibility between...
4.
Vester S, Davies A, Beavil R, Sandhar B, Beavil A, Gould H, et al.
Antibodies (Basel)
. 2023 Nov;
12(4).
PMID: 37987253
We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In...
5.
6.
Davies A, Beavil R, Barbolov M, Sandhar B, Gould H, Beavil A, et al.
Mol Immunol
. 2023 Jun;
159:28-37.
PMID: 37267832
Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the Fab region of IgD, based on four different...
7.
Kubagawa H, Skopnik C, Al-Qaisi K, Calvert R, Honjo K, Kubagawa Y, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34209905
Both non-immune "natural" and antigen-induced "immune" IgM are important for protection against pathogens and for regulation of immune responses to self-antigens. Since the bona fide IgM Fc receptor (FcµR) was...
8.
Ilkow V, Davies A, Dhaliwal B, Beavil A, Sutton B, McDonnell J
FEBS Open Bio
. 2021 Jun;
11(7):1827-1840.
PMID: 34075727
Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses. IgE's interaction with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor,...
9.
Skopnik C, Al-Qaisi K, Calvert R, Enghard P, Radbruch A, Sutton B, et al.
Front Immunol
. 2021 Feb;
11:618327.
PMID: 33584711
Both non-immune "natural" and antigen-induced "immune" IgM are important for protection against infections and for regulation of immune responses to self-antigens. The roles of its Fc receptor (FcµR) in these...
10.
Santos A, Barbosa-Morais N, Hurlburt B, Ramaswamy S, Hemmings O, Kwok M, et al.
Allergy
. 2020 Apr;
75(9):2309-2318.
PMID: 32248566
Background: Understanding the discrepancy between IgE sensitization and allergic reactions to peanut could facilitate diagnosis and lead to novel means of treating peanut allergy. Objective: To identify differences in IgE...