Richard Cubberley
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Explore the profile of Richard Cubberley including associated specialties, affiliations and a list of published articles.
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20
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141
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Recent Articles
1.
Wood A, Breffa C, Chaine C, Cubberley R, Dent M, Eichhorn J, et al.
Toxicology
. 2024 Jun;
506:153835.
PMID: 38857863
Next Generation Risk Assessment (NGRA) is an exposure-led approach to safety assessment that uses New Approach Methodologies (NAMs). Application of NGRA has been largely restricted to assessments of consumer use...
2.
Ip B, Madnick S, Zheng S, van Tongeren T, Hall S, Li H, et al.
Toxicol Sci
. 2024 Feb;
199(2):227-245.
PMID: 38335931
Chemicals in the systemic circulation can undergo hepatic xenobiotic metabolism, generate metabolites, and exhibit altered toxicity compared with their parent compounds. This article describes a 2-chamber liver-organ coculture model in...
3.
Sparham C, Ledbetter M, Cubberley R, Gore D, Sheffield D, Teixeira A, et al.
Chemosphere
. 2023 Nov;
346:140529.
PMID: 37914048
In this study water and sediment samples, collected from the River Nene (Northamptonshire) at several sites in the vicinity of the Great Billing sewage treatment plant (STP), were analysed for...
4.
Li H, Bunglawala F, Hewitt N, Pendlington R, Cubberley R, Nicol B, et al.
Toxicol Sci
. 2023 Aug;
196(1):1-15.
PMID: 37584694
Estimating human exposure in the safety assessment of chemicals is crucial. Physiologically based kinetic (PBK) models which combine information on exposure, physiology, and chemical properties, describing the absorption, distribution, metabolism,...
5.
Li H, Reynolds J, Sorrell I, Sheffield D, Pendlington R, Cubberley R, et al.
Toxicol Appl Pharmacol
. 2022 Mar;
442:115992.
PMID: 35346730
Combined with in vitro bioactivity data, physiologically based kinetic (PBK) models has increasing applications in next generation risk assessment for animal-free safety decision making. A tiered framework of building PBK...
6.
Parkinson E, Aleksic M, Kukic P, Bailey A, Cubberley R, Skipp P
Toxicology
. 2020 Sep;
445:152603.
PMID: 32991956
Haptenation of model nucleophiles, representing the key MIE in skin sensitisation, is routinely measured in chemico to provide data for skin allergy risk assessment. Better understanding of the dynamics of...
7.
Baltazar M, Cable S, Carmichael P, Cubberley R, Cull T, Delagrange M, et al.
Toxicol Sci
. 2020 Apr;
176(1):236-252.
PMID: 32275751
Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates new approach methodologies (NAMs) to assure safety without the use of animal testing. These principles were...
8.
Eilstein J, Gregoire S, Fabre A, Arbey E, Genies C, Duplan H, et al.
J Appl Toxicol
. 2020 Jan;
40(3):416-433.
PMID: 31912921
The abundance of xenobiotic metabolizing enzymes (XMEs) is different in the skin and liver; therefore, it is important to differentiate between liver and skin metabolism when applying the information to...
9.
Hewitt N, Gregoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, et al.
J Appl Toxicol
. 2019 Dec;
40(3):403-415.
PMID: 31867769
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic-relevant chemicals. The penetration of finite doses (10 μL/cm ) of chemicals was...
10.
Genies C, Jacques-Jamin C, Duplan H, Rothe H, Ellison C, Cubberley R, et al.
J Appl Toxicol
. 2019 Nov;
40(2):313-326.
PMID: 31701564
An understanding of the bioavailability of topically applied cosmetics ingredients is key to predicting their local skin and systemic toxicity and making a safety assessment. We investigated whether short-term incubations...