Richard Cubberley
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Explore the profile of Richard Cubberley including associated specialties, affiliations and a list of published articles.
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20
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141
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Recent Articles
11.
Parkinson E, Aleksic M, Arthur R, Regufe da Mota S, Cubberley R, Skipp P
Toxicol In Vitro
. 2019 Nov;
62:104697.
PMID: 31669365
The potential risk of skin sensitisation, associated with the development of allergic contact dermatitis (ACD), is a consideration in the safety assessment of new ingredients for use in personal care...
12.
Gregoire S, Cubberley R, Duplan H, Eilstein J, Hewitt N, Jacques-Jamin C, et al.
Skin Pharmacol Physiol
. 2019 Mar;
32(3):117-124.
PMID: 30889606
Background: We tested the cutaneous distribution of 50 chemicals in frozen human skin. The mass balance (MB) values for 48% of the chemicals were < 90%, possibly due to evaporation....
13.
Sanderson P, Simpson W, Cubberley R, Aleksic M, Gutsell S, Russell P
Toxicol Res (Camb)
. 2018 Aug;
5(1):34-44.
PMID: 30090324
Toxicological risk assessments in the 21 century are increasingly being driven by the Adverse Outcome Pathways (AOP) conceptual framework in which the Molecular Initiating Event (MIE) is of fundamental importance...
14.
Spriggs S, Cubberley R, Loadman P, Sheffield D, Wierzbicki A
Toxicol Lett
. 2018 May;
292:63-72.
PMID: 29709425
Understanding skin metabolism is key to improve in vitro to in vivo extrapolations used to inform risk assessments of topically applied products. However, published literature is scarce and usually covers...
15.
Desprez B, Dent M, Keller D, Klaric M, Ouedraogo G, Cubberley R, et al.
Toxicol In Vitro
. 2018 Mar;
50:137-146.
PMID: 29499337
When performing safety assessment of chemicals, the evaluation of their systemic toxicity based only on non-animal approaches is a challenging objective. The Safety Evaluation Ultimately Replacing Animal Test programme (SEURAT-1)...
16.
Parkinson E, Aleksic M, Cubberley R, Kaur-Atwal G, Vissers J, Skipp P
Toxicol Sci
. 2017 Dec;
162(2):429-438.
PMID: 29267982
Skin sensitization associated with the development of allergic contact dermatitis occurs via a number of specific key events at the cellular level. The molecular initiating event (MIE), the first in...
17.
Jacques-Jamin C, Duplan H, Rothe H, Vaillant O, Eilstein J, Gregoire S, et al.
Skin Pharmacol Physiol
. 2017 Jul;
30(5):234-245.
PMID: 28746940
Background: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting...
18.
Parkinson E, Boyd P, Aleksic M, Cubberley R, OConnor D, Skipp P
Toxicol Sci
. 2014 Aug;
142(1):239-49.
PMID: 25145658
The risk of contact sensitization is a major consideration in the development of new formulations for personal care products. However, developing a mechanistic approach for non-animal risk assessment requires further...
19.
Maxwell G, MacKay C, Cubberley R, Davies M, Gellatly N, Glavin S, et al.
Toxicol In Vitro
. 2013 Nov;
28(1):8-12.
PMID: 24184331
As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction...
20.
Koster S, Boobis A, Cubberley R, Hollnagel H, Richling E, Wildemann T, et al.
Food Chem Toxicol
. 2011 Apr;
49(8):1643-60.
PMID: 21457749
Unknown substances, not previously observed, are frequently detected in foods by quality control laboratories. In many cases, the assessment of these 'new' substances requires additional chemical analysis for their identification...