Alpha 2.0
Login Register
» Authors » Andreas Schepky

Andreas Schepky

Explore the profile of Andreas Schepky including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 45
Citations 414
Followers 0
Related Specialties
Toxicology
Pharmacology
Dermatology
Top 10 Co-Authors
Nicola J Hewitt
Martina Klaric
Sebastien Gregoire
Camille Genies
Daniela Lange
Helene Duplan
Jochen Kuhnl
Helga Rothe
Carine Jacques-Jamin
Abdulkarim Najjar
Published In
Regul Toxicol Pharmacol
J Appl Toxicol
Toxicol In Vitro
Front Pharmacol
ALTEX
Affiliations
Soon will be listed here.
Recent Articles
1.
The long way from raw data to NAM-based information: Overview on data layers and processing steps
Blum J, Brull M, Hengstler J, Dietrich D, Gruber A, Dipalo M, et al.
ALTEX . 2025 Jan; 42(1):167-180. PMID: 39817434
Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits....
2.
Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models
Najjar A, Hamadeh A, Krause S, Schepky A, Edginton A
CPT Pharmacometrics Syst Pharmacol . 2024 Nov; 13(12):2052-2067. PMID: 39498820
Sensitivity analyses are important components of physiologically based pharmacokinetic (PBPK) model development and are required by regulatory agencies for PBPK submissions. They assess the impact of parametric uncertainty and variability...
3.
Increasing Accessibility of Bayesian Network-Based Defined Approaches for Skin Sensitisation Potency Assessment
Mohoric T, Wilm A, Onken S, Milovich A, Logavoch A, Ankli P, et al.
Toxics . 2024 Sep; 12(9). PMID: 39330594
Skin sensitisation is a critical adverse effect assessed to ensure the safety of compounds and materials exposed to the skin. Alongside the development of new approach methodologies (NAMs), defined approaches...
4.
Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model
Genies C, Jeanjean C, Najjar A, Schepky A, Lange D, Kuhnl J, et al.
J Appl Toxicol . 2024 Aug; 45(2):210-221. PMID: 39191459
In a read-across assessment of the safety of genistein and daidzein in cosmetic products, additional information was required to account for differences in their systemic exposure after topical application in...
5.
Characterization of the in vitro penetration and first-pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full-thickness skin models
Genies C, Jeanjean C, Najjar A, Schepky A, Lange D, Kuhnl J, et al.
J Appl Toxicol . 2024 Aug; 45(2):200-209. PMID: 39191458
OECD test guideline compliant skin penetration studies, which also comply with the SCCS basic criteria, are lacking for genistein and daidzein. Therefore, we have measured their penetration and metabolism using...
6.
Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion
Najjar A, Kuhnl J, Lange D, Genies C, Jacques C, Fabian E, et al.
Front Pharmacol . 2024 Jul; 15:1421601. PMID: 38962304
We performed an exposure-based Next Generation Risk Assessment case read-across study using New Approach Methodologies (NAMs) to determine the highest safe concentration of daidzein in a body lotion, based on...
7.
Next generation risk assessment: an case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure
Ebmeyer J, Najjar A, Lange D, Boettcher M, Voss S, Brandmair K, et al.
Front Pharmacol . 2024 Mar; 15:1345992. PMID: 38515841
We performed an next-generation risk assessment (NGRA) for a fragrance ingredient, benzyl salicylate (BSal), to demonstrate how cosmetic ingredients can be evaluated for systemic toxicity endpoints based on non-animal approaches....
8.
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
Falckenhayn C, Bienkowska A, Sohle J, Wegner K, Raddatz G, Kristof B, et al.
Front Aging . 2024 Mar; 4:1258184. PMID: 38500495
Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired...
9.
Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein
Tao T, Brandmair K, Gerlach S, Przibilla J, Schepky A, Marx U, et al.
J Appl Toxicol . 2023 Sep; 44(2):287-300. PMID: 37700462
The HUMMIC skin-liver Chip2 microphysiological system using EpiDerm™ and HepaRG and stellate liver spheroids was used to evaluate the route-specific metabolism and toxicodynamic effects of genistein. Human-relevant exposure levels were...
10.
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene
Brandmair K, Tao T, Gerlach S, Przibilla J, Schepky A, Marx U, et al.
J Appl Toxicol . 2023 Sep; 44(3):333-343. PMID: 37699698
The HUMIMIC skin-liver Chip2 microphysiological systems model using the epidermal model, EpiDerm™, was reported previously to mimic application route-dependent metabolism of the hair dye, 4-amino-2-hydroxytoluene (AHT). Therefore, we evaluated the...