Sebastien Gregoire
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Explore the profile of Sebastien Gregoire including associated specialties, affiliations and a list of published articles.
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44
Citations
229
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Recent Articles
1.
Najjar A, Gregoire S, Nicol B, Natsch A, Golbamaki N, Boisleve F, et al.
Arch Toxicol
. 2025 Jan;
99(3):995-1010.
PMID: 39755907
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping...
2.
Sjovall P, Gregoire S, Wargniez W, Skedung L, Detroyer A, Luengo G
Sci Rep
. 2024 Aug;
14(1):18681.
PMID: 39134579
The interaction of active substances with molecular structures in stratum corneum (SC) is crucial for the efficacy and safety of cosmetic formulations and topical drugs. However, the molecular architecture of...
3.
Najjar A, Gregoire S, Nicol B, Natsch A, Golbamaki N, Boisleve F, et al.
Arch Toxicol
. 2024 Apr;
98(7):2199-2211.
PMID: 38658404
As part of the safety assessment of salicylate esters in cosmetics, we developed a metabolism factor based on in vitro to in vivo extrapolation (IVIVE) to provide a better estimation...
4.
Sextius P, Warrick E, Prevot-Gueguiniat A, Lereaux G, Boirre F, Baux L, et al.
Pigment Cell Melanoma Res
. 2024 Apr;
37(4):462-479.
PMID: 38560773
Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile...
5.
Gregoire S, Moustie A, Lereaux G, Roussel-Berlier L, Hewitt N
J Appl Toxicol
. 2024 Mar;
44(7):1067-1083.
PMID: 38539266
Case studies are needed to demonstrate the use of human-relevant New Approach Methodologies in cosmetics ingredient safety assessments. For read-across assessments, it is crucial to compare the target chemical with...
6.
Moore K, Gregoire S, Eilstein J, Begona Delgado-Charro M, Guy R
Mol Pharm
. 2024 Mar;
21(4):2058.
PMID: 38441041
No abstract available.
7.
Moore K, Gregoire S, Eilstein J, Begona Delgado-Charro M, Guy R
Mol Pharm
. 2023 Dec;
21(1):234-244.
PMID: 38060844
Assessing drug disposition in the skin after the application of a topical formulation is difficult. It is hypothesized that reverse iontophoresis (RI), which can extract charged/polar molecules for monitoring purposes,...
8.
Alepee N, Tourneix F, Singh A, Ade N, Gregoire S
ALTEX
. 2023 Jun;
40(4):606-618.
PMID: 37314401
The assessment of skin sensitizing properties of chemicals has moved away from animal methods to new approach methodologies (NAM), guided by qualitative mechanistic understanding operationalized in an adverse outcome pathway...
9.
Moore K, Reeksting S, Nair V, Pannakal S, Roy N, Eilstein J, et al.
RSC Adv
. 2023 Apr;
13(17):11261-11268.
PMID: 37057274
Plant metabolic profiling can provide a wealth of information regarding the biochemical status of the organism, but sample acquisition typically requires an invasive and/or destructive extraction process. Reverse iontophoresis (RI)...
10.
Eilstein J, Nair V, Moore K, Pannakal S, Gregoire S, Ekhar P, et al.
Phytochem Anal
. 2023 Mar;
34(4):408-413.
PMID: 36971356
Objective: We aimed to demonstrate the non-destructive, RI sampling of phytochemicals of interest from biomass from four different sources. Materials And Methods: RI experiments were performed in side-by-side diffusion cells...