Richard C Scarpulla
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Explore the profile of Richard C Scarpulla including associated specialties, affiliations and a list of published articles.
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19
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4072
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Recent Articles
1.
Buler M, Naessens T, Mattsson J, Morias Y, Soderberg M, Robbins P, et al.
FASEB Bioadv
. 2020 Aug;
2(8):453-463.
PMID: 32821877
PGC1α-Related Coactivator (PRC) is a transcriptional coactivator promoting cytokine expression in vitro in response to mitochondrial injury and oxidative stress, however, its physiological role has remained elusive. Herein we investigate...
2.
Gleyzer N, Scarpulla R
J Biol Chem
. 2016 Oct;
291(49):25529-25541.
PMID: 27789709
PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates...
3.
Gleyzer N, Scarpulla R
J Biol Chem
. 2013 Feb;
288(12):8004-8015.
PMID: 23364789
PGC-1-related coactivator (PRC), a growth-regulated member of the PGC-1 coactivator family, contributes to the expression of the mitochondrial respiratory apparatus. PRC also orchestrates a robust response to metabolic stress by...
4.
Scarpulla R, Vega R, Kelly D
Trends Endocrinol Metab
. 2012 Jul;
23(9):459-66.
PMID: 22817841
Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial...
5.
Scarpulla R
Biochim Biophys Acta
. 2011 Nov;
1819(9-10):1088-97.
PMID: 22080153
Nucleus-encoded regulatory factors are major contributors to mitochondrial biogenesis and function. Several act within the organelle to regulate mitochondrial transcription and translation while others direct the expression of nuclear genes...
6.
Gleyzer N, Scarpulla R
J Biol Chem
. 2011 Sep;
286(46):39715-25.
PMID: 21937425
PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of...
7.
Scarpulla R
Biochim Biophys Acta
. 2010 Oct;
1813(7):1269-78.
PMID: 20933024
The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function....
8.
Scarpulla R
Ann N Y Acad Sci
. 2008 Dec;
1147:321-34.
PMID: 19076454
Expression of the respiratory apparatus depends on both nuclear and mitochondrial genes. Although these genes are sequestered in distinct cellular organelles, their transcription relies on nucleus-encoded factors. Certain of these...
9.
Vercauteren K, Gleyzer N, Scarpulla R
J Biol Chem
. 2008 Nov;
284(4):2307-19.
PMID: 19036724
PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC...
10.
Scarpulla R
Physiol Rev
. 2008 Apr;
88(2):611-38.
PMID: 18391175
Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome (mtDNA). The entire protein...