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Natalie Gleyzer

Explore the profile of Natalie Gleyzer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 500
Followers 0
Related Specialties
Biochemistry
Cell Biology
Co-Authors
Richard C Scarpulla
Kristel Vercauteren
Vita Maria Marino
Raymond A Pasko
Published In
J Biol Chem
Mol Cell Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction
Gleyzer N, Scarpulla R
J Biol Chem . 2016 Oct; 291(49):25529-25541. PMID: 27789709
PGC-1-related coactivator (PRC) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates...
2.
Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence
Gleyzer N, Scarpulla R
J Biol Chem . 2013 Feb; 288(12):8004-8015. PMID: 23364789
PGC-1-related coactivator (PRC), a growth-regulated member of the PGC-1 coactivator family, contributes to the expression of the mitochondrial respiratory apparatus. PRC also orchestrates a robust response to metabolic stress by...
3.
PGC-1-related coactivator (PRC), a sensor of metabolic stress, orchestrates a redox-sensitive program of inflammatory gene expression
Gleyzer N, Scarpulla R
J Biol Chem . 2011 Sep; 286(46):39715-25. PMID: 21937425
PGC-1-related coactivator (PRC) is a growth-regulated transcriptional cofactor that activates many nuclear genes specifying mitochondrial respiratory function. Stable PRC silencing in U2OS cells results in a complex phenotype typical of...
4.
Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria
Vercauteren K, Gleyzer N, Scarpulla R
J Biol Chem . 2008 Nov; 284(4):2307-19. PMID: 19036724
PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC...
5.
PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression
Vercauteren K, Gleyzer N, Scarpulla R
J Biol Chem . 2008 Mar; 283(18):12102-11. PMID: 18343819
The PGC-1 family of regulated coactivators (PGC-1alpha, PGC-1beta, and PRC) plays an important role in directing respiratory gene expression in response to environmental signals. Here, we show that PRC and...
6.
PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth
Vercauteren K, Pasko R, Gleyzer N, Marino V, Scarpulla R
Mol Cell Biol . 2006 Aug; 26(20):7409-19. PMID: 16908542
PGC-1-related coactivator (PRC) was initially characterized as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. Both coactivators interact with nuclear respiratory factor 1 (NRF-1) and activate NRF-1...
7.
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
Gleyzer N, Vercauteren K, Scarpulla R
Mol Cell Biol . 2005 Feb; 25(4):1354-66. PMID: 15684387
In vertebrates, mitochondrial DNA (mtDNA) transcription is initiated bidirectionally from closely spaced promoters, HSP and LSP, within the D-loop regulatory region. Early studies demonstrated that mtDNA transcription requires mitochondrial RNA...