Richard C Scarpulla
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Explore the profile of Richard C Scarpulla including associated specialties, affiliations and a list of published articles.
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19
Citations
4072
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Recent Articles
11.
Vercauteren K, Gleyzer N, Scarpulla R
J Biol Chem
. 2008 Mar;
283(18):12102-11.
PMID: 18343819
The PGC-1 family of regulated coactivators (PGC-1alpha, PGC-1beta, and PRC) plays an important role in directing respiratory gene expression in response to environmental signals. Here, we show that PRC and...
12.
Vercauteren K, Pasko R, Gleyzer N, Marino V, Scarpulla R
Mol Cell Biol
. 2006 Aug;
26(20):7409-19.
PMID: 16908542
PGC-1-related coactivator (PRC) was initially characterized as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. Both coactivators interact with nuclear respiratory factor 1 (NRF-1) and activate NRF-1...
13.
Scarpulla R
J Cell Biochem
. 2005 Dec;
97(4):673-83.
PMID: 16329141
The mitochondrial respiratory apparatus is the product of both nuclear and mitochondrial genes. The protein coding capacity of mtDNA is restricted to the expression of 13 respiratory subunits and thus...
14.
Brunelle J, Bell E, Quesada N, Vercauteren K, Tiranti V, Zeviani M, et al.
Cell Metab
. 2005 Aug;
1(6):409-14.
PMID: 16054090
Mammalian cells detect decreases in oxygen concentrations to activate a variety of responses that help cells adapt to low oxygen levels (hypoxia). One such response is stabilization of the protein...
15.
Gleyzer N, Vercauteren K, Scarpulla R
Mol Cell Biol
. 2005 Feb;
25(4):1354-66.
PMID: 15684387
In vertebrates, mitochondrial DNA (mtDNA) transcription is initiated bidirectionally from closely spaced promoters, HSP and LSP, within the D-loop regulatory region. Early studies demonstrated that mtDNA transcription requires mitochondrial RNA...
16.
Cam H, Balciunaite E, Blais A, Spektor A, Scarpulla R, Young R, et al.
Mol Cell
. 2004 Nov;
16(3):399-411.
PMID: 15525513
Using genome-wide analysis of transcription factor occupancy, we investigated the mechanisms underlying three mammalian growth arrest pathways that require the pRB tumor suppressor family. We found that p130 and E2F4...
17.
18.
Scarpulla R
Biochim Biophys Acta
. 2002 May;
1576(1-2):1-14.
PMID: 12031478
The biogenesis of mitochondria requires the expression of a large number of genes, most of which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13...
19.
Scarpulla R
Gene
. 2002 Apr;
286(1):81-9.
PMID: 11943463
The biogenesis and function of mitochondria rely upon the regulated expression of nuclear genes. Recent evidence points to both transcriptional activators and coactivators as important mediators of mitochondrial maintenance and...