Ralph Scully
Overview
Explore the profile of Ralph Scully including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
4099
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Recent Articles
1.
Marin-Gonzalez A, Rybczynski A, Nilavar N, Nguyen D, Karwacki-Neisius V, Li A, et al.
bioRxiv
. 2025 Feb;
PMID: 39990468
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce formation of chromatin loops, with the break positioned at the loop...
2.
Kozlova N, Cruz K, Doh H, Ruzette A, Willis N, Hong S, et al.
bioRxiv
. 2025 Feb;
PMID: 39896456
Summary Paragraph: Drug resistance is a severe clinical problem in stroma-rich tumours, such as pancreatic ductal adenocarcinoma (PDAC), and patients often relapse within a few months on chemotherapy . The...
3.
Scully R, Glodzik D, Menghi F, Liu E, Zhang C
DNA Repair (Amst)
. 2025 Jan;
145:103802.
PMID: 39742573
Tandem duplications (TD) are among the most frequent type of structural variant (SV) in the cancer genome. They are characterized by a single breakpoint junction that defines the boundaries and...
4.
Elango R, Nilavar N, Li A, Nguyen D, Rass E, Duffey E, et al.
Mol Cell
. 2024 Dec;
85(1):78-90.e3.
PMID: 39631396
Replication fork collision with a DNA nick can generate a one-ended break, fostering genomic instability. The opposing fork's collision with the nick could form a second DNA end, enabling conservative...
5.
Scully R, Walter J, Nussenzweig A
DNA Repair (Amst)
. 2024 Nov;
144:103783.
PMID: 39504607
Replisome collision with a nicked parental DNA template can lead to the formation of a replication-associated double strand break (DSB). How this break is repaired has implications for cancer initiation,...
6.
Elango R, Nilavar N, Li A, Duffey E, Jiang Y, Nguyen D, et al.
bioRxiv
. 2024 Apr;
PMID: 38645103
Collision of a replication fork with a DNA nick is thought to generate a one-ended break, fostering genomic instability. Collision of the opposing converging fork with the nick could, in...
7.
Elango R, Panday A, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101551.
PMID: 36042887
In this protocol, we use CRISPR/Cas9 to generate large deletions of the entire coding region of a gene of interest, generating a hemizygous cell line. Next, we systematically engineer precise...
8.
Elango R, Panday A, Lach F, Willis N, Nicholson K, Duffey E, et al.
Nat Struct Mol Biol
. 2022 Aug;
29(8):801-812.
PMID: 35941380
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, 'unhooking' the ICL and forming a double strand break (DSB) that is...
9.
Panday A, Elango R, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101529.
PMID: 35928003
Chromatin immunoprecipitation coupled with quantitative PCR (ChIP-qPCR) even with optimization may give low signal-to-background ratio and spatial resolution. Here, we adapted Cleavage Under Targets and Release Using Nuclease (CUT&RUN) (originally...
10.
Adeyemi R, Willis N, Elia A, Clairmont C, Li S, Wu X, et al.
Mol Cell
. 2021 Oct;
81(21):4440-4456.e7.
PMID: 34597596
Protection of stalled replication forks is critical to genomic stability. Using genetic and proteomic analyses, we discovered the Protexin complex containing the ssDNA binding protein SCAI and the DNA polymerase...