Pieter Van der Veken
Overview
Explore the profile of Pieter Van der Veken including associated specialties, affiliations and a list of published articles.
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140
Citations
1574
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Recent Articles
11.
Espadinha M, De Loose J, Corthaut S, Thys S, Van Rymenant Y, Verhulst E, et al.
Eur J Med Chem
. 2024 Apr;
270:116389.
PMID: 38593588
Dipeptidyl peptidases (DPP) 8 and 9 are intracellular serine proteases that play key roles in various biological processes and recent findings highlight DPP8 and DPP9 as potential therapeutic targets for...
12.
Weiner L, FitzGerald A, Maynard R, Marcisak E, Nasir A, Glasgow E, et al.
Res Sq
. 2024 Jan;
PMID: 38196606
Natural killer (NK) cells play a critical role in physiologic and pathologic conditions such as pregnancy, infection, autoimmune disease and cancer. In cancer, numerous strategies have been designed to exploit...
13.
Poulie C, Shalgunov V, Elvas F, Van Rymenant Y, Moon E, Battisti U, et al.
Eur J Med Chem
. 2023 Oct;
262:115862.
PMID: 37883899
Small-molecular fibroblast activation protein inhibitor (FAPI)-based tracer have been shown to be promising Positron Emission Tomography (PET) Ga-labeled radiopharmaceuticals to image a variety of tumors including pancreatic, breast, and colorectal...
14.
Adhikari K, Dewulf J, Vangestel C, Van der Veken P, Stroobants S, Elvas F, et al.
ACS Omega
. 2023 Oct;
8(41):38252-38262.
PMID: 37867688
The pretargeted imaging strategy using inverse electron demand Diels-Alder (IEDDA) cycloaddition between a -cyclooctene (TCO) and tetrazine (Tz) has emerged and rapidly grown as a promising concept to improve radionuclide...
15.
Benramdane S, De Loose J, Filippi N, Espadinha M, Beyens O, Van Rymenant Y, et al.
J Med Chem
. 2023 Sep;
66(18):12717-12738.
PMID: 37721854
Dipeptidyl peptidase 9 (DPP9) is a proline-selective serine protease that plays a key role in NLRP1- and CARD8-mediated inflammatory cell death (pyroptosis). No selective inhibitors have hitherto been reported for...
16.
Scarpellini C, Valembois S, Goossens K, Vadi M, Lanthier C, Klejborowska G, et al.
Front Chem
. 2023 Apr;
11:1160164.
PMID: 37090247
Receptor-Interacting serine/threonine-Protein Kinase 1 (RIPK1) emerged as an important driver of inflammation and, consequently, inflammatory pathologies. The enzymatic activity of RIPK1 is known to indirectly promote inflammation by triggering cell...
17.
Martin M, Ballal S, Yadav M, Bal C, Van Rymenant Y, De Loose J, et al.
Cancers (Basel)
. 2023 Mar;
15(6).
PMID: 36980775
Radiopharmaceuticals based on the highly potent FAP inhibitor (FAPi) UAMC-1110 have shown great potential in molecular imaging, but the short tumor retention time of the monomers do not match the...
18.
Ramos-Llorca A, Decraecker L, Cacheux V, Zeiburlina I, De Bruyn M, Battut L, et al.
Front Chem
. 2023 Jan;
10:1089959.
PMID: 36688031
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The...
19.
Benramdane S, De Loose J, Beyens O, Van Rymenant Y, Vliegen G, Augustyns K, et al.
ChemMedChem
. 2022 Jun;
17(15):e202200097.
PMID: 35760756
Vildagliptin is a marketed DPP4 inhibitor, used in the management of type 2 diabetes. The molecule also has notable DPP8/9 affinity, with some preference for DPP9. Therefore, we aimed to...
20.
Bracke A, De Hert E, De Bruyn M, Claesen K, Vliegen G, Vujkovic A, et al.
Clin Chim Acta
. 2022 Mar;
531:4-11.
PMID: 35283094
Background: COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation...