Simon Scharpe
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Explore the profile of Simon Scharpe including associated specialties, affiliations and a list of published articles.
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65
Citations
1621
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Recent Articles
1.
Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpe S, et al.
Basic Res Cardiol
. 2013 Apr;
108(3):350.
PMID: 23608773
Atherosclerosis is a chronic inflammatory disorder of the arterial wall leading to coronary artery disease, stroke, and peripheral arterial disease. Along with the discovery of dipeptidyl peptidase 4 (DPP4) as...
2.
Matheeussen V, Lambeir A, Jungraithmayr W, Gomez N, Mc Entee K, Van der Veken P, et al.
Clin Chim Acta
. 2011 Nov;
413(3-4):456-62.
PMID: 22093941
Background: Dipeptidyl peptidase IV (DPPIV, DPP4) is a serine protease that releases N-terminal dipeptides. It is a validated drug target for type 2 diabetes and DPPIV inhibitors are currently evaluated...
3.
Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure
Gomez N, Touihri K, Matheeussen V, Da Costa A, Mahmoudabady M, Mathieu M, et al.
Eur J Heart Fail
. 2011 Nov;
14(1):14-21.
PMID: 22045924
Aims: Recent studies indicate that brain natriuretic peptide (BNP(1-32)) may be truncated into BNP(3-32) by dipeptidyl peptidase IV (DPP4) and that BNP(3-32) has reduced biological activities compared with BNP(1-32). We...
4.
Matheeussen V, Baerts L, De Meyer G, De Keulenaer G, Van der Veken P, Augustyns K, et al.
Biol Chem
. 2011 Jan;
392(3):189-98.
PMID: 21194356
Dipeptidyl peptidase IV (DPPIV)/CD26 is by far the most extensively studied member of the prolyl oligopeptidase family of serine proteases. The discovery of the related enzymes DPP8 and DPP9 necessitates...
5.
Brouns R, Verkerk R, Aerts T, De Surgeloose D, Wauters A, Scharpe S, et al.
Neurochem Res
. 2010 May;
35(9):1315-22.
PMID: 20490917
Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA). We investigated whether activity...
6.
Dubois V, Lambeir A, Vandamme S, Matheeussen V, Guisez Y, Scharpe S, et al.
Biochim Biophys Acta
. 2009 Dec;
1804(4):781-8.
PMID: 20026260
The dipeptidyl peptidases (DPP) 8 and 9 belong to the DPP4 activity and/or structure homologues (DASH). Recently, a DPP9-like protein was purified from bovine testes. The aim of the present...
7.
Jungraithmayr W, De Meester I, Matheeussen V, Inci I, Augustyns K, Scharpe S, et al.
Peptides
. 2009 Dec;
31(4):585-91.
PMID: 20018218
The T cell activation Ag CD26/dipeptidylpeptidase IV (DPP IV) combines co-stimulatory and enzymatic properties. Catalytically, it functions as an exopeptidase, modulating biological activity of key chemokines and peptides. Here we...
8.
Jungraithmayr W, Oberreiter B, De Meester I, Wiedl T, Inci I, Bain M, et al.
Transplantation
. 2009 Aug;
88(4):478-85.
PMID: 19696630
Background: Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect...
9.
Kim Y, Myint A, Verkerk R, Scharpe S, Steinbusch H, Leonard B
Neuropsychobiology
. 2009 Apr;
59(2):123-9.
PMID: 19390223
Cytokine imbalances especially between T helper type (Th) 1 and Th2 and tryptophan breakdown were reported to be involved in the pathophysiology of schizophrenia. The hyperactive inflammatory response system could...
10.
Zhai W, Jungraithmayr W, De Meester I, Inci I, Augustyns K, Arni S, et al.
Transplantation
. 2009 Apr;
87(8):1140-6.
PMID: 19384159
Background: Enzymatic activity inhibition of CD26/dipeptidylpeptidase IV (CD26/DPP IV) attenuated short-term post-Tx (transplantation) ischemia-reperfusion injury after 18-hr-ischemia. Here, we investigated the effect of intragraft CD26/DPP IV catalytic inhibition on primary...