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Louis Maes

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Articles 259
Citations 3449
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Recent Articles
1.
Ilbeigi K, Mabille D, Matheeussen A, Hendrickx R, Claes M, Van Reet N, et al.
ACS Infect Dis . 2024 Dec; 11(1):131-143. PMID: 39665421
African trypanosomiasis is a widespread disease of human and veterinary importance caused by various with a globally devastating impact and a need for novel treatment options. We here provide a...
2.
Slafer B, Dessoy M, de Oliveira R, Mollo M, Lee E, Matheeussen A, et al.
ACS Omega . 2024 May; 9(20):22360-22370. PMID: 38799347
Chagas disease (CD) is a parasitic neglected tropical disease (NTD) caused by the protozoan that affects 6 million people worldwide, often resulting in financial burden, morbidity, and mortality in endemic...
3.
Hendrickx S, Feijens P, Escudie F, Chatelain E, Maes L, Caljon G
ACS Infect Dis . 2024 May; 10(6):2101-2107. PMID: 38733389
The bioluminescent BALB/c mouse model was used to evaluate the parasiticidal drug action kinetics of the reference drugs miltefosine, paromomycin, sodium stibogluconate, and liposomal amphotericin B. Infected mice were treated...
4.
Dirkx L, Van Acker S, Nicolaes Y, Cunha J, Ahmad R, Hendrickx R, et al.
PLoS Pathog . 2024 Apr; 20(4):e1012181. PMID: 38656959
Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum and L. donovani parasites rapidly enter into quiescence...
5.
Gendron T, Lanfranchi D, Wenzel N, Kessedjian H, Jannack B, Maes L, et al.
Molecules . 2024 Apr; 29(7). PMID: 38611899
2,6-Diaryl-4-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect. Novel diastereoselective methodologies were developed and generalized...
6.
Trometer N, Pecourneau J, Feng L, Navarro-Huerta J, Lazarin-Bidoia D, de Oliveira Silva Lautenschlager S, et al.
ACS Infect Dis . 2024 Apr; 10(5):1808-1838. PMID: 38606978
Chagas disease, or American trypanosomiasis, is a neglected tropical disease which is a top priority target of the World Health Organization. The disease, endemic mainly in Latin America, is caused...
7.
Zheng Y, van den Kerkhof M, Ibrahim M, de Esch I, Maes L, Sterk G, et al.
J Med Chem . 2024 Feb; 67(4):2849-2863. PMID: 38330051
Human African trypanosomiasis (HAT) still faces few therapeutic options and emerging drug resistance, stressing an urgency for novel antitrypanosomal drug discovery. Here, we describe lead optimization efforts aiming at improving...
8.
Braillard S, Keenan M, Breese K, Heppell J, Abbott M, Islam R, et al.
Sci Transl Med . 2023 Dec; 15(726):eadh9902. PMID: 38091406
New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new...
9.
Zheng Y, van den Kerkhof M, van der Meer T, Gul S, Kuzikov M, Ellinger B, et al.
J Med Chem . 2023 Jul; 66(15):10252-10264. PMID: 37471520
Human African Trypanosomiasis (HAT), caused by , is one of the neglected tropical diseases with a continuing need for new medication. We here describe the discovery of 5-phenylpyrazolopyrimidinone analogs as...
10.
Zheng Y, Matheeussen A, Maes L, Caljon G, Sterk G, Leurs R
Molecules . 2023 Jul; 28(13). PMID: 37446602
Malaria continues to pose a significant health threat, causing thousands of deaths each year. The limited availability of vaccines and medications, combined with the emergence of drug resistance, further complicates...