Philippe Delagrange
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Explore the profile of Philippe Delagrange including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Konietzny A, Han Y, Popp Y, van Bommel B, Sharma A, Delagrange P, et al.
J Cell Sci
. 2024 Mar;
137(8).
PMID: 38525600
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axons. To maintain neuronal polarity, the axon...
2.
Grignard J, Lamamy V, Vermersch E, Delagrange P, Stephan J, Dorval T, et al.
PLoS Comput Biol
. 2022 Jun;
18(6):e1010236.
PMID: 35759459
Microtubules and their post-translational modifications are involved in major cellular processes. In severe diseases such as neurodegenerative disorders, tyrosinated tubulin and tyrosinated microtubules are in lower concentration. We present here...
3.
Tsotinis A, Afroudakis P, Papanastasiou I, Sakellaropoulou A, Boniakou M, Komiotis D, et al.
ChemMedChem
. 2022 Apr;
17(12):e202200129.
PMID: 35478275
A series of substituted indolo[2,1-a]isoquinolines and indolo[1,2-a]benzoxazines have been prepared, as melatonin analogues, to investigate the nature of the binding site of the melatonin receptor. Agonist and antagonist potency of...
4.
Peris L, Parato J, Qu X, Soleilhac J, Lante F, Kumar A, et al.
Brain
. 2022 Feb;
145(7):2486-2506.
PMID: 35148384
Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin,...
5.
Ettaoussi M, Laversin A, Vreulz B, Rami M, Lebegue N, Delagrange P, et al.
ChemMedChem
. 2021 Nov;
17(3):e202100658.
PMID: 34797951
In our constant search for new successors of agomelatine, we report herein a new series of compounds resulting from bioisosteric modulation of the naphthalene ring. The isoquinoline and tetrahydroisoquinoline derivatives...
6.
Shabajee-Alibay P, Bonnaud A, Malpaux B, Delagrange P, Audinot V, Yous S, et al.
J Pharmacol Exp Ther
. 2021 Oct;
380(1).
PMID: 34706966
In mammals, MT and MT melatonin receptors are high affinity G protein-coupled receptors and are thought to be involved in the integration of the melatonin signaling throughout the brain and...
7.
Lepinay J, Taragnat C, Dubois J, Chesneau D, Jockers R, Delagrange P, et al.
PLoS One
. 2021 Jul;
16(7):e0255249.
PMID: 34324562
Melatonin (MLT) is a biological modulator of circadian and seasonal rhythms and reproduction. The photoperiodic information is detected by retinal photoreceptors and transmitted through nerve transmissions to the pineal gland,...
8.
Belloch F, Beltran E, Venzala E, Montalt-Tordera J, Diaz-Perdigon T, Cecon E, et al.
Eur Neuropsychopharmacol
. 2021 Jan;
44:51-65.
PMID: 33451856
Circadian rhythms disturbance is widely observable in patients with major depression (MD) and is also associated with depression vulnerability. Of them, disturbed melatonin secretion rhythm is particularly relevant to MD...
9.
Gerbier R, Ndiaye-Lobry D, Martinez de Morentin P, Cecon E, Heisler L, Delagrange P, et al.
FASEB J
. 2020 Nov;
35(1):e21161.
PMID: 33156577
Association of G protein-coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation remains a challenge. Our recent in vitro...
10.
Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine
Bolteau R, Descamps F, Ettaoussi M, Caignard D, Delagrange P, Melnyk P, et al.
Eur J Med Chem
. 2020 Feb;
189:112078.
PMID: 32004937
For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands....