Mohamed Ettaoussi
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Explore the profile of Mohamed Ettaoussi including associated specialties, affiliations and a list of published articles.
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17
Citations
60
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Recent Articles
1.
Lopez-Canul M, He Q, Sasson T, Ettaoussi M, De Gregorio D, Ochoa-Sanchez R, et al.
J Neurosci
. 2024 May;
44(29).
PMID: 38744530
Sleep disorders affect millions of people around the world and have a high comorbidity with psychiatric disorders. While current hypnotics mostly increase non-rapid eye movement sleep (NREMS), drugs acting selectively...
2.
Ettaoussi M, Laversin A, Vreulz B, Rami M, Lebegue N, Delagrange P, et al.
ChemMedChem
. 2021 Nov;
17(3):e202100658.
PMID: 34797951
In our constant search for new successors of agomelatine, we report herein a new series of compounds resulting from bioisosteric modulation of the naphthalene ring. The isoquinoline and tetrahydroisoquinoline derivatives...
3.
Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine
Bolteau R, Descamps F, Ettaoussi M, Caignard D, Delagrange P, Melnyk P, et al.
Eur J Med Chem
. 2020 Feb;
189:112078.
PMID: 32004937
For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands....
4.
Kufareva I, Bestgen B, Brear P, Prudent R, Laudet B, Moucadel V, et al.
Sci Rep
. 2019 Nov;
9(1):15893.
PMID: 31685885
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
5.
Comai S, Lopez-Canul M, De Gregorio D, Posner A, Ettaoussi M, Guarnieri F, et al.
Pharmacol Res
. 2019 Apr;
144:343-356.
PMID: 31029764
Melatonin (MLT), a neuromodulator mainly acting through two G-protein coupled receptors MT and MT, regulates many brain functions, including circadian rhythms, mood, pain and sleep. MLT and non-selective MT/MT receptor...
6.
Duroux R, Rami M, Landagaray E, Ettaoussi M, Caignard D, Delagrange P, et al.
Eur J Med Chem
. 2017 Nov;
141:552-566.
PMID: 29102176
We recently reported a series of naphthofuranic compounds as constrained agomelatine analogues. Herein, in order to explore alternative ethyl amide side chain rigidification, naphthocyclopentane and quinolinocyclopentane derivatives with various acetamide...
7.
Landagaray E, Ettaoussi M, Rami M, Boutin J, Caignard D, Delagrange P, et al.
Eur J Med Chem
. 2017 Jan;
127:621-631.
PMID: 28131094
New series of melatonergic ligands issued from two methoxy-quinolinic scaffolds (2-MQ and 3-MQ), were designed and synthesized. Herein we report the synthetic scheme and pharmacological results of the new prepared...
8.
Landagaray E, Ettaoussi M, Duroux R, Boutin J, Caignard D, Delagrange P, et al.
Eur J Med Chem
. 2016 Jan;
109:360-70.
PMID: 26820449
Following our research for new melatonergic ligands, herein we report the design, synthesis and biological evaluation of new series of naphthofuranic derivatives as MT1 and MT2 ligands. Binding affinity results...
9.
Ettaoussi M, Peres B, Errazani A, Boutin J, Caignard D, Delagrange P, et al.
Eur J Med Chem
. 2014 Dec;
90:822-33.
PMID: 25528336
In this paper we report the investigation of C-3 and β-acetamide positions of agomelatine analogues. Concomitant insertion of a hydroxymethyl in the β-acetamide position and aliphatic groups in C-3 position...
10.
Lipka E, Landagaray E, Ettaoussi M, Yous S, Vaccher C
Electrophoresis
. 2014 Jun;
35(19):2785-92.
PMID: 24888767
Performing CD-EKC, baseline separation of five agomelatine analogs, potential antidepressant compounds, was achieved. A method for the enantioresolution and determination of enantiomeric purity of these naphthalene derivatives was developed using...