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Ariane R Pessentheiner

Explore the profile of Ariane R Pessentheiner including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 554
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Recent Articles
1.
Pessentheiner A, Spann N, Autran C, Oh T, Grunddal K, Coker J, et al.
JCI Insight . 2024 Sep; 9(21). PMID: 39325548
Macrophages contribute to the induction and resolution of inflammation and play a central role in chronic low-grade inflammation in cardiovascular diseases caused by atherosclerosis. Human milk oligosaccharides (HMOs) are complex...
2.
Amor M, Bianco V, Buerger M, Lechleitner M, Vujic N, Dobrijevic A, et al.
Cardiovasc Diabetol . 2023 Nov; 22(1):327. PMID: 38017481
Background: Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases...
3.
Trieger G, Pessentheiner A, Purcell S, Green C, DeForest N, Willert K, et al.
J Biol Chem . 2023 Mar; 299(5):104611. PMID: 36931394
Adipose tissue plays a crucial role in maintaining metabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like adipose tissue become insulin resistant, decompensation...
4.
Tillo M, Lamanna W, Dwyer C, Sandoval D, Pessentheiner A, Al-Azzam N, et al.
J Biol Chem . 2022 Jun; 298(8):102159. PMID: 35750212
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase...
5.
Ramms B, Patel S, Sun X, Pessentheiner A, Ducasa G, Mullick A, et al.
JCI Insight . 2022 Jun; 7(13). PMID: 35653195
Apolipoprotein C-III (apoC-III) is a critical regulator of triglyceride metabolism and correlates positively with hypertriglyceridemia and cardiovascular disease (CVD). It remains unclear if therapeutic apoC-III lowering reduces CVD risk and...
6.
Pessentheiner A, Ducasa G, Gordts P
Front Immunol . 2020 Jun; 11:769. PMID: 32508807
Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and...
7.
Paschoal V, Walenta E, Talukdar S, Pessentheiner A, Osborn O, Hah N, et al.
Cell Metab . 2020 May; 31(6):1173-1188.e5. PMID: 32413335
G protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing effects. But whether these two pathways functionally interact and can be leveraged together to markedly improve insulin resistance...
8.
Hofer D, Zirkovits G, Pelzmann H, Huber K, Pessentheiner A, Xia W, et al.
FASEB J . 2019 Oct; 33(12):13808-13824. PMID: 31638418
-acetylaspartate (NAA) is synthesized by aspartate -acetyltransferase (gene: ) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role...
9.
Ramms B, Patel S, Nora C, Pessentheiner A, Chang M, Green C, et al.
J Lipid Res . 2019 May; 60(8):1379-1395. PMID: 31092690
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator...
10.
Xia W, Pessentheiner A, Hofer D, Amor M, Schreiber R, Schoiswohl G, et al.
Cell Rep . 2018 May; 23(7):1948-1961. PMID: 29768196
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required...