Philip L S M Gordts
Overview
Explore the profile of Philip L S M Gordts including associated specialties, affiliations and a list of published articles.
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62
Citations
2738
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Recent Articles
11.
Weiss R, Spahn P, Chiang A, Liu Q, Li J, Hamill K, et al.
Nat Chem Biol
. 2022 Mar;
18(5):575.
PMID: 35354934
No abstract available.
12.
Kawanishi K, Coker J, Grunddal K, Dhar C, Hsiao J, Zengler K, et al.
Arterioscler Thromb Vasc Biol
. 2021 Sep;
41(11):2730-2739.
PMID: 34587757
Objective: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor N-acetylneuraminic acid (Neu5Ac). With metabolic nonhuman Neu5Gc incorporation...
13.
Weiss R, Spahn P, Chiang A, Liu Q, Li J, Hamill K, et al.
Nat Chem Biol
. 2021 Apr;
17(6):684-692.
PMID: 33846619
Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by...
14.
Sandoval D, Clausen T, Nora C, Cribbs A, Denardo A, Clark A, et al.
bioRxiv
. 2021 Apr;
PMID: 33791697
We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone , a compound in clinical trials for anti-fibrotic and anti-inflammatory applications , as a potent inhibitor of SARS-CoV-2 infection and replication. The...
15.
Clausen T, Sandoval D, Spliid C, Pihl J, Perrett H, Painter C, et al.
Cell
. 2020 Sep;
183(4):1043-1057.e15.
PMID: 32970989
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent...
16.
Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, et al.
J Biol Chem
. 2020 Jul;
295(30):10508.
PMID: 32709762
No abstract available.
17.
Clausen T, Sandoval D, Spliid C, Pihl J, Painter C, Thacker B, et al.
bioRxiv
. 2020 Jul;
PMID: 32699853
We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding...
18.
19.
Pessentheiner A, Ducasa G, Gordts P
Front Immunol
. 2020 Jun;
11:769.
PMID: 32508807
Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and...
20.
Weiss R, Spahn P, Gomez Toledo A, Chiang A, Kellman B, Li J, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(17):9311-9317.
PMID: 32277030
Heparin is the most widely prescribed biopharmaceutical in production globally. Its potent anticoagulant activity and safety makes it the drug of choice for preventing deep vein thrombosis and pulmonary embolism....