Peter J Woodruff
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Explore the profile of Peter J Woodruff including associated specialties, affiliations and a list of published articles.
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12
Citations
236
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Recent Articles
1.
Kalera K, Liu R, Lim J, Pathirage R, Swanson D, Johnson U, et al.
ACS Infect Dis
. 2024 Mar;
10(4):1391-1404.
PMID: 38485491
Tuberculosis (TB), caused by (Mtb), is the leading cause of death worldwide by infectious disease. Treatment of Mtb infection requires a six-month course of multiple antibiotics, an extremely challenging regimen...
2.
Kalera K, Stothard A, Woodruff P, Swarts B
Chem Commun (Camb)
. 2020 Sep;
56(78):11528-11547.
PMID: 32914793
Trehalose, a disaccharide of glucose, is increasingly recognized as an important contributor to virulence in major bacterial pathogens, such as Mycobacterium tuberculosis, Clostridioides difficile, and Burkholderia pseudomallei. Accordingly, bacterial trehalose...
3.
Danielson N, Collins J, Stothard A, Dong Q, Kalera K, Woodruff P, et al.
Chem Commun (Camb)
. 2019 Apr;
55(34):5009-5012.
PMID: 30968891
Trehalose is used as an additive in thousands of foods, cosmetics, and pharmaceutical products, and it is being investigated as a therapeutic for multiple human diseases. However, its ability to...
4.
Pena-Zalbidea S, Huang A, Kavunja H, Salinas B, Desco M, Drake C, et al.
Carbohydr Res
. 2018 Nov;
472:16-22.
PMID: 30428395
Trehalose analogues bearing fluorescent and click chemistry tags have been developed as probes of bacterial trehalose metabolism, but these tools have limitations with respect to in vivo imaging applications. Here,...
5.
Groenevelt J, Meints L, Stothard A, Poston A, Fiolek T, Finocchietti D, et al.
J Org Chem
. 2018 Jul;
83(15):8662-8667.
PMID: 29973045
Trehalosamine (2-amino-2-deoxy-α,α-d-trehalose) is an aminoglycoside with antimicrobial activity against Mycobacterium tuberculosis, and it is also a versatile synthetic intermediate used to access imaging probes for mycobacteria. To overcome inefficient chemical...
6.
ONeill M, Piligian B, Olson C, Woodruff P, Swarts B
Pure Appl Chem
. 2017 Dec;
89(9):1223-1249.
PMID: 29225379
Trehalose is a non-reducing sugar whose ability to stabilize biomolecules has brought about its widespread use in biological preservation applications. Trehalose is also an essential metabolite in a number of...
7.
Wolber J, Urbanek B, Meints L, Piligian B, Lopez-Casillas I, Zochowski K, et al.
Carbohydr Res
. 2017 Sep;
450:60-66.
PMID: 28917089
Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian disaccharide trehalose. Trehalose metabolism is essential for mycobacterial viability and has been...
8.
Meints L, Poston A, Piligian B, Olson C, Badger K, Woodruff P, et al.
J Vis Exp
. 2017 Mar;
(120).
PMID: 28287534
Chemically modified versions of trehalose, or trehalose analogues, have applications in biology, biotechnology, and pharmaceutical science, among other fields. For instance, trehalose analogues bearing detectable tags have been used to...
9.
Rundell S, Wagar Z, Meints L, Olson C, ONeill M, Piligian B, et al.
Org Biomol Chem
. 2016 Aug;
14(36):8598-609.
PMID: 27560008
Mycobacterium tuberculosis, the etiological agent of human tuberculosis, requires the non-mammalian disaccharide trehalose for growth and virulence. Recently, detectable trehalose analogues have gained attention as probes for studying trehalose metabolism...
10.
Urbanek B, Wing D, Haislop K, Hamel C, Kalscheuer R, Woodruff P, et al.
Chembiochem
. 2014 Aug;
15(14):2066-70.
PMID: 25139066
Trehalose analogues are emerging as valuable tools for investigating Mycobacterium tuberculosis, but progress in this area is slow due to the difficulty in synthesizing these compounds. Here, we report a...