Alicyn I Stothard
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Explore the profile of Alicyn I Stothard including associated specialties, affiliations and a list of published articles.
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8
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106
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Recent Articles
1.
Kalera K, Liu R, Lim J, Pathirage R, Swanson D, Johnson U, et al.
ACS Infect Dis
. 2024 Mar;
10(4):1391-1404.
PMID: 38485491
Tuberculosis (TB), caused by (Mtb), is the leading cause of death worldwide by infectious disease. Treatment of Mtb infection requires a six-month course of multiple antibiotics, an extremely challenging regimen...
2.
Kalera K, Stothard A, Woodruff P, Swarts B
Chem Commun (Camb)
. 2020 Sep;
56(78):11528-11547.
PMID: 32914793
Trehalose, a disaccharide of glucose, is increasingly recognized as an important contributor to virulence in major bacterial pathogens, such as Mycobacterium tuberculosis, Clostridioides difficile, and Burkholderia pseudomallei. Accordingly, bacterial trehalose...
3.
Marten A, Stothard A, Kalera K, Swarts B, Conway M
J Med Entomol
. 2020 Jan;
57(4):1096-1103.
PMID: 31982917
Trehalose is a disaccharide that is the major sugar found in insect hemolymph fluid. Trehalose provides energy, and promotes growth, metamorphosis, stress recovery, chitin synthesis, and insect flight. The hydrolysis...
4.
Zhang Y, Shaikh N, Ferey J, Wankhade U, Chintapalli S, Higgins C, et al.
Gastroenterology
. 2019 Dec;
158(5):1402-1416.e2.
PMID: 31838076
Background & Aims: Trehalose is a disaccharide that might be used in the treatment of cardiometabolic diseases. However, trehalose consumption promotes the expansion of Clostridioides difficile ribotypes that metabolize trehalose...
5.
Danielson N, Collins J, Stothard A, Dong Q, Kalera K, Woodruff P, et al.
Chem Commun (Camb)
. 2019 Apr;
55(34):5009-5012.
PMID: 30968891
Trehalose is used as an additive in thousands of foods, cosmetics, and pharmaceutical products, and it is being investigated as a therapeutic for multiple human diseases. However, its ability to...
6.
Zhang Y, Higgins C, Fortune H, Chen P, Stothard A, Mayer A, et al.
Nat Commun
. 2019 Apr;
10(1):1587.
PMID: 30962478
Caloric restriction and intermittent fasting are emerging therapeutic strategies against obesity, insulin resistance and their complications. However, the effectors that drive this response are not completely defined. Here we identify...
7.
Higgins C, Zhang Y, Mayer A, Fujiwara H, Stothard A, Graham M, et al.
JCI Insight
. 2018 Aug;
3(16).
PMID: 30135298
The hepatic glucose fasting response is gaining traction as a therapeutic pathway to enhance hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic effects remain unclear. Here, we demonstrate...
8.
Groenevelt J, Meints L, Stothard A, Poston A, Fiolek T, Finocchietti D, et al.
J Org Chem
. 2018 Jul;
83(15):8662-8667.
PMID: 29973045
Trehalosamine (2-amino-2-deoxy-α,α-d-trehalose) is an aminoglycoside with antimicrobial activity against Mycobacterium tuberculosis, and it is also a versatile synthetic intermediate used to access imaging probes for mycobacteria. To overcome inefficient chemical...