Peter J Espenshade
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Explore the profile of Peter J Espenshade including associated specialties, affiliations and a list of published articles.
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65
Citations
2888
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Recent Articles
1.
Ishida C, Myers S, Kubota C, Shao W, McGuire M, Liu C, et al.
Cancer Res Commun
. 2024 Sep;
4(9):2539-2552.
PMID: 39240063
Significance: Our findings demonstrate that SREBP pathway activation is a critical part of the metabolic reprogramming that occurs in PDAC development and progression. Therefore, targeting the SREBP pathway has significant...
2.
Ishida C, Kubota C, Carlyle E, Tsukamoto T, Espenshade P
ACS Chem Biol
. 2024 Aug;
19(8):1695-1704.
PMID: 39106256
Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of lipid homeostasis and are essential for lipid metabolic reprogramming that supports tumor growth in multiple cancers. SREBP pathway inhibitors...
3.
Kubota C, Myers S, Seppala T, Burkhart R, Espenshade P
Mol Metab
. 2024 Jun;
85:101964.
PMID: 38823776
Objective: Cancer cells must maintain lipid supplies for their proliferation and do so by upregulating lipogenic gene programs. The sterol regulatory element-binding proteins (SREBPs) act as modulators of lipid homeostasis...
4.
Kubota C, Myers S, Seppala T, Burkhart R, Espenshade P
bioRxiv
. 2024 May;
PMID: 38746286
Cancer cells must maintain lipid supplies for their proliferation and do so by upregulating lipogenic gene programs. The sterol regulatory element-binding proteins (SREBPs) act as modulators of lipid homeostasis by...
5.
Ishida C, Myers S, Shao W, McGuire M, Liu C, Kubota C, et al.
bioRxiv
. 2024 Feb;
PMID: 38370699
Significance: Our findings demonstrate that SREBP pathway activation is a critical part of the metabolic reprogramming that occurs in PDAC development and progression. Therefore, targeting the SREBP pathway has significant...
6.
Phulara N, Ishida C, Espenshade P, Seneviratne H
Drug Metab Dispos
. 2024 Feb;
52(4):288-295.
PMID: 38331874
Gemcitabine (dFdC) and emtricitabine (FTC) are first-line drugs that are used for the treatment of pancreatic cancer and human immunodeficiency virus, respectively. The above drugs must undergo sequential phosphorylation to...
7.
Bolshette N, Ezagouri S, Dandavate V, Karavaeva I, Golik M, Wang H, et al.
PLoS Biol
. 2023 Nov;
21(11):e3002367.
PMID: 37967106
In mammals, O2 and CO2 levels are tightly regulated and are altered under various pathological conditions. While the molecular mechanisms that participate in O2 sensing are well characterized, little is...
8.
Ishida C, Shao W, Espenshade P
Methods Mol Biol
. 2022 Dec;
2557:755-764.
PMID: 36512249
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate the uptake and synthesis of cholesterol and fatty acids in mammalian cells. SREBP cleavage-activating protein (SCAP)...
9.
Laffin J, Shao W, Espenshade P
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Dec;
1868(2):159260.
PMID: 36494027
No abstract available.
10.
McGuire M, Espenshade P
Pharmacol Ther
. 2022 Dec;
241:108326.
PMID: 36463977
Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding protein that has been implicated in a wide range of cell and tissue functions, including cytochromes P450 activity, heme homeostasis, cancer,...