Peter J Espenshade
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Explore the profile of Peter J Espenshade including associated specialties, affiliations and a list of published articles.
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65
Citations
2888
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Recent Articles
11.
Zhao S, Hughes A, Espenshade P
MicroPubl Biol
. 2022 Sep;
2022.
PMID: 36090151
Fission yeast Dap1 is a heme binding protein required for cytochromes P450 activity. Here, we tested whether Dap1 axial coordination of heme iron is required for its role in the...
12.
Osborne T, Espenshade P
J Clin Invest
. 2022 Jun;
132(11).
PMID: 35642642
Nonalcoholic fatty liver disease (NAFLD) is a major health concern that often associates with obesity and diabetes. Fatty liver is usually a benign condition, yet a fraction of individuals progress...
13.
Kubota C, Espenshade P
Cancer Res
. 2022 Mar;
82(9):1682-1688.
PMID: 35294526
Cancer cells are demarcated from normal cells by distinct biological hallmarks, including the reprogramming of metabolic processes. One of the key players involved in metabolic reprogramming is stearoyl-CoA desaturase (SCD),...
14.
McGuire M, Mukhopadhyay D, Myers S, Mosher E, Brookheart R, Kammers K, et al.
J Biol Chem
. 2021 Oct;
297(5):101316.
PMID: 34678314
Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein implicated in a wide range of cellular functions. We previously showed that PGRMC1 binds to cytochromes P450 in yeast and...
15.
Shao W, Hwang J, Liu C, Mukhopadhyay D, Zhao S, Shen M, et al.
J Biol Chem
. 2020 Oct;
295(52):18284-18300.
PMID: 33109611
Oxygen regulates hypoxia-inducible factor (HIF) transcription factors to control cell metabolism, erythrogenesis, and angiogenesis. Whereas much has been elucidated about how oxygen regulates HIF, whether lipids affect HIF activity is...
16.
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
Esquejo R, Roqueta-Rivera M, Shao W, Phelan P, Seneviratne U, Am Ende C, et al.
Cell Chem Biol
. 2020 Oct;
28(2):169-179.e7.
PMID: 33096051
Sterol regulatory element-binding proteins (SREBPs) are master transcriptional regulators of the mevalonate pathway and lipid metabolism and represent an attractive therapeutic target for lipid metabolic disorders. SREBPs are maintained in...
17.
Gutierrez M, Campusano S, Gonzalez A, Gomez M, Barahona S, Sepulveda D, et al.
Front Microbiol
. 2019 Apr;
10:586.
PMID: 30984134
is a basidiomycete yeast that synthesizes carotenoids, mainly astaxanthin, which are of great commercial interest. Currently, there are many unknown aspects related to regulatory mechanisms on the synthesis of carotenoids...
18.
Bettridge K, Cook A, Ziegelstein R, Espenshade P
Mol Cell
. 2018 Sep;
71(6):879-881.
PMID: 30241604
Data on the perceptions of scientists suggest a moderate public distrust of scientist's motivations. Bettridge et al. suggest scientist's reluctance to engage the public on controversial ethical issues may be...
19.
Clasen S, Shao W, Gu H, Espenshade P
Elife
. 2017 Oct;
6.
PMID: 29083304
The prolyl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic response in fission yeast by controlling activity of the sterol regulatory element-binding protein transcription factor Sre1. Here, we identify...
20.
Burr R, Espenshade P
Semin Cell Dev Biol
. 2017 Aug;
81:110-120.
PMID: 28851600
Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order...