Peter D Williams
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Explore the profile of Peter D Williams including associated specialties, affiliations and a list of published articles.
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20
Citations
204
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Recent Articles
1.
Nowak R, Levy F, Chaillou E, Cornilleau F, Cognie J, Marnet P, et al.
Front Endocrinol (Lausanne)
. 2021 Feb;
11:612651.
PMID: 33628199
The neuropeptide oxytocin (OT) promotes maternal care and social affiliation in adults but its importance in infant attachment still remains unknown. True animal models of infant attachment are extremely rare,...
2.
Bungard C, Williams P, Schulz J, Wiscount C, Holloway M, Loughran H, et al.
ACS Med Chem Lett
. 2017 Dec;
8(12):1292-1297.
PMID: 29259750
Using the HIV-1 protease binding mode of and as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core...
3.
Stump C, Cooke A, Bruno J, Cabalu T, Gotter A, Harell C, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5809-5814.
PMID: 27818110
While a correlation between blockade of the orexin 2 receptor (OXR) with either a dual orexin receptor antagonist (DORA) or a selective orexin 2 receptor antagonist (2-SORA) and a decrease...
4.
Bungard C, Williams P, Ballard J, Bennett D, Beaulieu C, Bahnck-Teets C, et al.
ACS Med Chem Lett
. 2016 Jul;
7(7):702-7.
PMID: 27437081
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled...
5.
Raheem I, Breslin M, Bruno J, Cabalu T, Cooke A, Cox C, et al.
Bioorg Med Chem Lett
. 2015 Jan;
25(3):444-50.
PMID: 25577040
Highly selective orexin receptor antagonists (SORAs) of the orexin 2 receptor (OX2R) have become attractive targets both as potential therapeutics for insomnia as well as biological tools to help further...
6.
Isaacs R, Newton C, Cutrona K, Mercer S, Payne L, Stauffer K, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(5):1536-40.
PMID: 21295467
A novel 1,3,5-trisubstituted benzamide thrombin inhibitor template was designed via hybridization of a known aminopyridinoneacetamide and a known 1,3,5-trisubstituted phenyl ether. Optimization of this lead afforded a novel potent series...
7.
Williams P, Staas D, Venkatraman S, Loughran H, Ruzek R, Booth T, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(22):6754-7.
PMID: 20869872
Optimization studies using an HIV RNase H active site inhibitor containing a 1-hydroxy-1,8-naphthyridin-2(1H)-one core identified 4-position substituents that provided several potent and selective inhibitors. The best compound was potent and...
8.
Su H, Yan Y, Sridhar Prasad G, Smith R, Daniels C, Abeywickrema P, et al.
J Virol
. 2010 May;
84(15):7625-33.
PMID: 20484498
HIV/AIDS continues to be a menace to public health. Several drugs currently on the market have successfully improved the ability to manage the viral burden in infected patients. However, new...
9.
Lu M, Ngo W, Mei Y, Munshi V, Burlein C, Loughran M, et al.
Protein Expr Purif
. 2010 Jan;
71(2):231-9.
PMID: 20060474
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) plays an essential role in the life cycle of the virus. Therefore, RT has been a primary target in the development...
10.
Wiscount C, Williams P, Tran L, Embrey M, Fisher T, Sherman V, et al.
Bioorg Med Chem Lett
. 2008 Jul;
18(16):4581-3.
PMID: 18657970
A series of 10-hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones was synthesized and tested for their inhibition of HIV-1 replication in cell culture. Structure-activity studies indicated that high antiviral potency against wild-type virus as well as...