Rebecca B White
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Explore the profile of Rebecca B White including associated specialties, affiliations and a list of published articles.
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20
Citations
132
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Recent Articles
1.
Staas D, Bell I, Burgey C, Deng J, Gallicchio S, Lim J, et al.
Bioorg Med Chem Lett
. 2024 Sep;
112:129944.
PMID: 39233187
A novel series of 3-amino-piperidin-2-one-based calcitonin gene-related peptide (CGRP) receptor antagonists was invented based upon the discovery of unexpected structure-activity observations. Initial exploration of the structure-activity relationships enabled the generation...
2.
Moore E, Bell I, Fraley M, Burgey C, White R, Li C, et al.
Cephalalgia
. 2024 Jan;
44(1):3331024231226186.
PMID: 38215228
Background: The trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) is identified as an essential element in migraine pathogenesis. Methods: and studies evaluated pharmacologic properties of the CGRP receptor antagonist atogepant....
3.
Moore E, Fraley M, Bell I, Burgey C, White R, Li C, et al.
J Pharmacol Exp Ther
. 2020 Jan;
373(1).
PMID: 31992609
A growing body of evidence has implicated the calcitonin gene-related peptide (CGRP) receptors in migraine pathophysiology. With the recent approval of monoclonal antibodies targeting CGRP or the CGRP receptor, the...
4.
Crowley B, Stump C, Nguyen D, Potteiger C, McWherter M, Paone D, et al.
Bioorg Med Chem Lett
. 2015 Aug;
25(21):4777-4781.
PMID: 26231160
In our efforts to develop CGRP receptor antagonists as backups to MK-3207, 2, we employed a scaffold hopping approach to identify a series of novel oxazolidinone-based compounds. The development of...
5.
Bell I, Gallicchio S, Stump C, Bruno J, Fan H, Gantert L, et al.
ACS Med Chem Lett
. 2014 Jun;
4(9):863-8.
PMID: 24900761
Rational modification of the potent calcitonin gene-related peptide (CGRP) receptor antagonist MK-3207 led to a series of analogues with enhanced CNS penetrance and a convenient chemical handle for introduction of...
6.
Nanda K, Henze D, Della Penna K, Desai R, Leitl M, Lemaire W, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(4):1218-21.
PMID: 24461289
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
7.
Bell I, Stump C, Gallicchio S, Staas D, Blair Zartman C, Moore E, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):3941-5.
PMID: 22607672
Rational modification of the clinically tested CGRP receptor antagonist MK-3207 (3) afforded an analogue with increased unbound fraction in rat plasma and enhanced aqueous solubility, 2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide (MK-8825) (6). Compound 6...
8.
Trotter B, Nanda K, Burgey C, Potteiger C, Deng J, Green A, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(8):2354-8.
PMID: 21420860
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and...
9.
Manley P, Zartman A, Paone D, Burgey C, Henze D, Della Penna K, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(8):2359-64.
PMID: 21420857
A novel series of decahydroquinoline CB2 agonists is described. Optimization of the amide substituent led to improvements in CB2/CB1 selectivity as well as physical properties. Two key compounds were examined...
10.
Isaacs R, Newton C, Cutrona K, Mercer S, Dorsey B, McDonough C, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(5):1532-5.
PMID: 21295466
Although the S3 pocket of the thrombin active site is lined with lipophilic amino acid residues, the accommodation of polarity within the lipophilic P3 moiety of small molecule inhibitors is...