Per-Eric Lund
Overview
Explore the profile of Per-Eric Lund including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
409
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ibrahim H, Balboa D, Saarimaki-Vire J, Montaser H, Dyachok O, Lund P, et al.
Diabetologia
. 2024 May;
67(8):1642-1662.
PMID: 38743124
Aims/hypothesis: Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7 is significantly enriched in the Finnish population, with almost 1:250 individuals as...
2.
Golec E, Ekstrom A, Noga M, Omar-Hmeadi M, Lund P, Villoutreix B, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2120083119.
PMID: 35666870
Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so...
3.
Balboa D, Barsby T, Lithovius V, Saarimaki-Vire J, Omar-Hmeadi M, Dyachok O, et al.
Nat Biotechnol
. 2022 Mar;
40(7):1042-1055.
PMID: 35241836
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of...
4.
Omar-Hmeadi M, Lund P, Gandasi N, Tengholm A, Barg S
Nat Commun
. 2020 Apr;
11(1):1896.
PMID: 32312960
Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose. Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through insulin and somatostatin. To understand...
5.
Liin S, Lund P, Larsson J, Brask J, Wallner B, Elinder F
J Gen Physiol
. 2018 Jul;
150(8):1215-1230.
PMID: 30002162
Voltage-gated ion channels are key molecules for the generation of cellular electrical excitability. Many pharmaceutical drugs target these channels by blocking their ion-conducting pore, but in many cases, channel-opening compounds...
6.
Gandasi N, Yin P, Riz M, Chibalina M, Cortese G, Lund P, et al.
J Clin Invest
. 2017 May;
127(6):2353-2364.
PMID: 28481223
Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic β...
7.
Ottosson N, Wu X, Nolting A, Karlsson U, Lund P, Ruda K, et al.
Sci Rep
. 2015 Aug;
5:13278.
PMID: 26299574
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not...
8.
Revell J, Lund P, Linley J, Metcalfe J, Burmeister N, Sridharan S, et al.
Peptides
. 2013 Mar;
44:40-6.
PMID: 23523779
The spider venom peptide Huwentoxin-IV (HwTx-IV) 1 is a potent antagonist of hNav1.7 (IC50 determined herein as 17 ± 2 nM). Nav1.7 is a voltage-gated sodium channel involved in the...
9.
Kalezic I, Luo L, Lund P, Eriksson A, Bueters T, Visser S
Pharm Res
. 2013 Feb;
30(5):1409-22.
PMID: 23371514
Purpose: In vivo and ex vivo inhibition of ectopic activity of clinically used and newly developed sodium channel (NaV) blockers were quantified in the rat spinal nerve ligation (SNL) model...
10.
Kers I, Macsari I, Csjernyik G, Nylof M, Skogholm K, Sandberg L, et al.
Bioorg Med Chem Lett
. 2012 Sep;
22(19):6108-15.
PMID: 22939696
The Na(V)1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene coding for the channel protein and...