Muhmmad Omar-Hmeadi
Overview
Explore the profile of Muhmmad Omar-Hmeadi including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
381
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0
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Recent Articles
1.
Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine L, et al.
Nat Metab
. 2024 Jul;
6(7):1329-1346.
PMID: 39009762
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated insulin resistance is characterized by decreased...
2.
Ibrahim H, Balboa D, Saarimaki-Vire J, Montaser H, Dyachok O, Lund P, et al.
Diabetologia
. 2024 May;
67(8):1642-1662.
PMID: 38743124
Aims/hypothesis: Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7 is significantly enriched in the Finnish population, with almost 1:250 individuals as...
3.
Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor A, et al.
Nat Metab
. 2024 Apr;
6(5):861-879.
PMID: 38565923
White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms underlying cellular specialization during...
4.
Ludzki A, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, et al.
Sci Adv
. 2024 Jan;
10(1):eadi2689.
PMID: 38170777
Defects in adipocyte lipolysis drive multiple aspects of cardiometabolic disease, but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen...
5.
Couchet M, Gao H, Klingelhuber F, Jalkanen J, de Castro Barbosa T, Omar-Hmeadi M, et al.
Adipocyte
. 2023 Nov;
:2283213.
PMID: 37982546
Background: Mature adipocytes are notoriously difficult to study ex vivo and alternative cell culture systems have therefore been developed. One of the most common models are human adipose progenitor cells...
6.
Omar-Hmeadi M, Gucek A, Barg S
Cell Rep
. 2023 Jan;
42(2):112036.
PMID: 36701234
Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P) is an important signaling phospholipid that is required for regulated exocytosis and some forms of endocytosis. The two processes share a topologically similar pore structure that connects the...
7.
Omar-Hmeadi M, Liu L, Echeverry S, Barg S
Methods Mol Biol
. 2022 Oct;
2565:179-186.
PMID: 36205894
Hormones and neurotransmitters are released from (neuro)endocrine cells by regulated exocytosis of secretory granules. During exocytosis, the granule membrane fuses with the plasma membrane, which allows release of the stored...
8.
Golec E, Ekstrom A, Noga M, Omar-Hmeadi M, Lund P, Villoutreix B, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2120083119.
PMID: 35666870
Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so...
9.
Balboa D, Barsby T, Lithovius V, Saarimaki-Vire J, Omar-Hmeadi M, Dyachok O, et al.
Nat Biotechnol
. 2022 Mar;
40(7):1042-1055.
PMID: 35241836
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of...
10.
Omar-Hmeadi M, Idevall-Hagren O
Cell Mol Life Sci
. 2020 Nov;
78(5):1957-1970.
PMID: 33146746
Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone stimulates glucose uptake and suppresses glucose production. Defects in both the availability and action of insulin...