Penelope A Andreux
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Explore the profile of Penelope A Andreux including associated specialties, affiliations and a list of published articles.
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17
Citations
2394
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Recent Articles
1.
Liu S, Faitg J, Tissot C, Konstantopoulos D, Laws R, Bourdier G, et al.
iScience
. 2025 Mar;
28(2):111814.
PMID: 40034121
Cardiovascular diseases (CVDs) remain the primary cause of global mortality. Nutritional interventions hold promise to reduce CVD risks in an increasingly aging population. However, few nutritional interventions are proven to...
2.
Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler P, Braun A, et al.
Immunity
. 2022 Nov;
55(11):2059-2073.e8.
PMID: 36351375
T memory stem cells (T) display increased self-renewal and prolonged survival capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell responses. T cells can be expanded by...
3.
DAmico D, Olmer M, Fouassier A, Valdes P, Andreux P, Rinsch C, et al.
Aging Cell
. 2022 Jul;
21(8):e13662.
PMID: 35778837
Osteoarthritis (OA) is the most common age-related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation...
4.
Singh A, DAmico D, Andreux P, Fouassier A, Blanco-Bose W, Evans M, et al.
Cell Rep Med
. 2022 May;
3(5):100633.
PMID: 35584623
Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where...
5.
Singh A, DAmico D, Andreux P, DunnGalvin G, Kern T, Blanco-Bose W, et al.
Eur J Clin Nutr
. 2021 Jun;
76(2):297-308.
PMID: 34117375
Background: Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and in humans. Not everyone has a...
6.
DAmico D, Andreux P, Valdes P, Singh A, Rinsch C, Auwerx J
Trends Mol Med
. 2021 May;
27(7):687-699.
PMID: 34030963
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts....
7.
Luan P, DAmico D, Andreux P, Laurila P, Wohlwend M, Li H, et al.
Sci Transl Med
. 2021 Apr;
13(588).
PMID: 33827972
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD,...
8.
Andreux P, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, et al.
Nat Metab
. 2020 Jul;
1(6):595-603.
PMID: 32694802
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Here, we report the...
9.
Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly
Andreux P, van Diemen M, Heezen M, Auwerx J, Rinsch C, Groeneveld G, et al.
Sci Rep
. 2019 Nov;
9(1):17821.
PMID: 31767924
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
10.
Andreux P, van Diemen M, Heezen M, Auwerx J, Rinsch C, Groeneveld G, et al.
Sci Rep
. 2018 Jun;
8(1):8548.
PMID: 29867098
Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia. While these two conditions...