Evan G Williams
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Explore the profile of Evan G Williams including associated specialties, affiliations and a list of published articles.
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41
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2707
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Recent Articles
1.
Bender A, Ranea-Robles P, Williams E, Williams E, Mirzaian M, Heimel J, et al.
bioRxiv
. 2025 Mar;
PMID: 40027804
For many inborn errors of metabolism (IEM) the understanding of disease mechanisms remains limited in part explaining their unmet medical needs. We hypothesize that the expressivity of IEM disease phenotypes...
2.
Xu F, Ziebarth J, Goeminne L, Gao J, Williams E, Quarles L, et al.
J Nutr Biochem
. 2023 Jun;
119:109398.
PMID: 37302664
Plasma lipids are modulated by gene variants and many environmental factors, including diet-associated weight gain. However, understanding how these factors jointly interact to influence molecular networks that regulate plasma lipid...
3.
Li H, Perino A, Huang Q, Von Alvensleben G, Banaei-Esfahani A, Velazquez-Villegas L, et al.
Cell Metab
. 2022 Sep;
34(10):1594-1610.e4.
PMID: 36099916
Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chow- or high-fat-diet-fed...
4.
Sharma V, Fossati A, Ciuffa R, Buljan M, Williams E, Chen Z, et al.
Brief Bioinform
. 2022 Jun;
23(4).
PMID: 35724564
In molecular biology, it is a general assumption that the ensemble of expressed molecules, their activities and interactions determine biological function, cellular states and phenotypes. Stable protein complexes-or macromolecular machines-are,...
5.
Addicks G, Zhang H, Ryu D, Vasam G, Green A, Marshall P, et al.
J Cell Biol
. 2022 Jan;
221(2).
PMID: 35024765
Protein lysine acetylation is a post-translational modification that regulates protein structure and function. It is targeted to proteins by lysine acetyltransferases (KATs) or removed by lysine deacetylases. This work identifies...
6.
Williams E, Pfister N, Roy S, Statzer C, Haverty J, Ingels J, et al.
Cell Syst
. 2021 Oct;
13(1):43-57.e6.
PMID: 34666007
We profiled the liver transcriptome, proteome, and metabolome in 347 individuals from 58 isogenic strains of the BXD mouse population across age (7 to 24 months) and diet (low or...
7.
Roy S, Sleiman M, Jha P, Ingels J, Chapman C, McCarty M, et al.
Nat Metab
. 2021 Sep;
3(9):1217-1227.
PMID: 34552269
How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in...
8.
cuklina J, Lee C, Williams E, Sajic T, Collins B, Rodriguez Martinez M, et al.
Mol Syst Biol
. 2021 Aug;
17(8):e10240.
PMID: 34432947
Advancements in mass spectrometry-based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much-needed statistical power, handling them introduces technical variability known as batch effects....
9.
van der Kolk B, Saari S, Lovric A, Arif M, Alvarez M, Ko A, et al.
Cell Rep Med
. 2021 May;
2(4):100226.
PMID: 33948567
Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49...
10.
Ashbrook D, Arends D, Prins P, Mulligan M, Roy S, Williams E, et al.
Cell Syst
. 2021 Jan;
12(3):235-247.e9.
PMID: 33472028
The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to...