Patrick Aebischer
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Explore the profile of Patrick Aebischer including associated specialties, affiliations and a list of published articles.
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100
Citations
5576
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Recent Articles
1.
Singh A, DAmico D, Andreux P, Fouassier A, Blanco-Bose W, Evans M, et al.
Cell Rep Med
. 2022 May;
3(5):100633.
PMID: 35584623
Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where...
2.
Liu S, DAmico D, Shankland E, Bhayana S, Garcia J, Aebischer P, et al.
JAMA Netw Open
. 2022 Jan;
5(1):e2144279.
PMID: 35050355
Importance: Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A is a natural gut microbiome-derived food metabolite that has been shown to stimulate mitophagy...
3.
Rochat C, Bernard-Marissal N, Kallstig E, Pradervand S, Perrin F, Aebischer P, et al.
Glia
. 2022 Jan;
70(5):842-857.
PMID: 34978340
In amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, both cell-autonomous and noncell-autonomous mechanisms lead to the selective degeneration of motoneurons (MN). Here, we evaluate the therapeutic potential of...
4.
Singh A, DAmico D, Andreux P, DunnGalvin G, Kern T, Blanco-Bose W, et al.
Eur J Clin Nutr
. 2021 Jun;
76(2):297-308.
PMID: 34117375
Background: Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and in humans. Not everyone has a...
5.
Andreux P, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, et al.
Nat Metab
. 2020 Jul;
1(6):595-603.
PMID: 32694802
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Here, we report the...
6.
Lei H, Dirren E, Poitry-Yamate C, Schneider B, Gruetter R, Aebischer P
J Cereb Blood Flow Metab
. 2018 Feb;
39(7):1283-1298.
PMID: 29400109
In vivo H magnetic resonance spectroscopy (H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to...
7.
Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider B
Mol Neurodegener
. 2017 Nov;
12(1):80.
PMID: 29100525
Background: Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson's disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore...
8.
Zheng L, Bernard-Marissal N, Moullan N, DAmico D, Auwerx J, Moore D, et al.
Hum Mol Genet
. 2017 Jan;
26(3):582-598.
PMID: 28053050
To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD,...
9.
Andrews M, Soleman S, Cheah M, Tumbarello D, Mason M, Moloney E, et al.
eNeuro
. 2016 Aug;
3(4).
PMID: 27570822
The regenerative ability of CNS axons decreases with age, however, this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of...
10.
Ryu D, Mouchiroud L, Andreux P, Katsyuba E, Moullan N, Nicolet-Dit-Felix A, et al.
Nat Med
. 2016 Jul;
22(8):879-88.
PMID: 27400265
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as...