Laurent Mouchiroud
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Explore the profile of Laurent Mouchiroud including associated specialties, affiliations and a list of published articles.
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39
Citations
3818
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Recent Articles
1.
Gao A, El Alam G, Zhu Y, Li W, Sulc J, Li X, et al.
Cell Rep
. 2024 Oct;
43(10):114836.
PMID: 39368088
Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we...
2.
Gao A, El Alam G, Zhu Y, Li W, Katsyuba E, Sulc J, et al.
bioRxiv
. 2024 Jan;
PMID: 38293129
Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we...
3.
Mottis A, Li T, El Alam G, Rapin A, Katsyuba E, Liaskos D, et al.
J Clin Invest
. 2022 Jul;
132(17).
PMID: 35787521
Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial...
4.
Hegde R, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, et al.
EMBO J
. 2020 Aug;
39(17):e104671.
PMID: 32757223
Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of...
5.
Letizia M, Cornaglia M, Trouillon R, Sorrentino V, Mouchiroud L, Sleiman M, et al.
Microsyst Nanoeng
. 2019 May;
4:6.
PMID: 31057896
The organism is a performant model system for studying human biological processes and diseases, but until now all phenome data are produced as population-averaged read-outs. Monitoring of individual responses to...
6.
Baris Atakan H, Cornaglia M, Mouchiroud L, Auwerx J, Gijs M
Lab Chip
. 2018 Nov;
19(1):120-135.
PMID: 30484462
The nematode Caenorhabditis elegans is increasingly used as a model for human biology. However, in vivo culturing platforms for C. elegans allowing high-content phenotyping during their life cycle in an...
7.
Migliozzi D, Cornaglia M, Mouchiroud L, Uhlmann V, Unser M, Auwerx J, et al.
J Biomed Opt
. 2018 Nov;
24(2):1-9.
PMID: 30484295
A major step for the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Caenorhabditis elegans is...
8.
Dong L, Cornaglia M, Krishnamani G, Zhang J, Mouchiroud L, Lehnert T, et al.
PLoS One
. 2018 Mar;
13(3):e0193989.
PMID: 29509812
The nematode Caenorhabditis elegans is an important model organism for biomedical research and genetic studies relevant to human biology and disease. Such studies are often based on high-resolution imaging of...
9.
Sorrentino V, Romani M, Mouchiroud L, Beck J, Zhang H, DAmico D, et al.
Nature
. 2017 Dec;
552(7684):187-193.
PMID: 29211722
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-β peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients...
10.
Trouillon R, Letizia M, Menzies K, Mouchiroud L, Auwerx J, Schoonjans K, et al.
Integr Biol (Camb)
. 2017 Aug;
9(10):810-819.
PMID: 28853753
Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be...