Payal R Sheth
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Explore the profile of Payal R Sheth including associated specialties, affiliations and a list of published articles.
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23
Citations
498
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Recent Articles
1.
Satapati S, Downes D, Metzger D, Shankaran H, Talukdar S, Zhou Y, et al.
SLAS Discov
. 2022 Jan;
27(1):20-28.
PMID: 35058172
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions....
2.
Wen X, Liu C, Ghislain L, Tovar K, Shah V, Stout S, et al.
Anal Chem
. 2021 Apr;
93(15):6071-6079.
PMID: 33819010
The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of members, and identify those that modulate...
3.
Downes D, Kasumov T, Daurio N, Wood N, Previs M, Sheth P, et al.
Metabolites
. 2020 Nov;
10(11).
PMID: 33233825
Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, H-water is quite versatile, and its incorporation into various products can enable measurements of carbohydrate, lipid,...
4.
Daurio N, Zhou H, Chen Y, Sheth P, Imbriglio J, McLaren D, et al.
ACS Chem Biol
. 2020 Sep;
15(10):2623-2635.
PMID: 32930572
The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to...
5.
Downes D, Zhong W, Zhang J, Chen B, Satapati S, Metzger D, et al.
J Am Soc Mass Spectrom
. 2020 Aug;
31(12):2421-2425.
PMID: 32840373
Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in neutral lipid laser desorption analytical approaches. Here,...
6.
Hernandez L, Kroh H, Hsieh E, Yang X, Beaumont M, Sheth P, et al.
J Mol Biol
. 2017 Feb;
429(7):1030-1044.
PMID: 28232034
The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced by the bacterial pathogen Clostridium difficile and are responsible for the pathology associated with C. difficile infection (CDI). The...
7.
Berejnaia O, Wang H, Labroli M, Yang C, Gill C, Xiao J, et al.
Anal Biochem
. 2016 Nov;
518:9-15.
PMID: 27815077
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created an urgent need for new therapeutic agents capable of combating this threat. We have previously reported on the discovery of novel...
8.
Yang S, Pan J, Yang C, Labroli M, Pan W, Caldwell J, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(19):4743-4747.
PMID: 27575474
A series of benzimidazole analogs have been synthesized to improve the profile of the previous lead compounds tarocin B and 1. The syntheses, structure-activity relationships, and selected biochemical data of...
9.
Mann P, Muller A, Wolff K, Fischmann T, Wang H, Reed P, et al.
PLoS Pathog
. 2016 May;
12(5):e1005585.
PMID: 27144276
Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels...
10.
Lee S, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, et al.
Sci Transl Med
. 2016 Mar;
8(329):329ra32.
PMID: 26962156
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S....