Paul L Fox
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Explore the profile of Paul L Fox including associated specialties, affiliations and a list of published articles.
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128
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5681
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Recent Articles
1.
Zin I, China A, Khan K, Nag J, Vasu K, Deshpande G, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(30):e2303642121.
PMID: 39012819
Glutamyl-prolyl-tRNA synthetase (EPRS1) is a bifunctional aminoacyl-tRNA-synthetase (aaRS) essential for decoding the genetic code. EPRS1 resides, with seven other aaRSs and three noncatalytic proteins, in the cytoplasmic multi-tRNA synthetase complex...
2.
Bharti R, Dey G, Khan D, Myers A, Huffman O, Saygin C, et al.
Mol Cancer
. 2024 Jun;
23(1):121.
PMID: 38853277
Background: Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our...
3.
Khan D, Ramachandiran I, Vasu K, China A, Khan K, Cumbo F, et al.
Nat Commun
. 2024 May;
15(1):4284.
PMID: 38769304
Hypomyelinating leukodystrophy (HLD) is an autosomal recessive disorder characterized by defective central nervous system myelination. Exome sequencing of two siblings with severe cognitive and motor impairment and progressive hypomyelination characteristic...
4.
Khan D, Fox P
Viruses
. 2024 Mar;
16(3).
PMID: 38543832
Viruses are obligate, intracellular parasites that co-opt host cell machineries for propagation. Critical among these machineries are those that translate RNA into protein and their mechanisms of control. Most regulatory...
5.
Troike K, Wang S, Silver D, Lee J, Mulkearns-Hubert E, Hajdari N, et al.
Neurooncol Adv
. 2024 Jan;
6(1):vdad154.
PMID: 38239626
Background: Glioblastoma (GBM) displays alterations in iron that drive proliferation and tumor growth. Iron regulation is complex and involves many regulatory mechanisms, including the homeostatic iron regulator () gene, which...
6.
Khan D, Fox P
Biochem Soc Trans
. 2023 Dec;
51(6):2127-2141.
PMID: 38108455
Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that serve a foundational role in the efficient and accurate translation of genetic information from messenger RNA to proteins. These proteins play critical, non-canonical...
7.
Jia J, Arif A, Willard B, Smith J, Stuehr D, Hazen S, et al.
Mol Cell
. 2023 Nov;
83(21):3941.
PMID: 37922873
No abstract available.
8.
Vasu K, Ramachandiran I, Chechi A, Khan K, Khan D, Kaufman R, et al.
RNA Biol
. 2023 Sep;
20(1):737-749.
PMID: 37702393
Adiponectin, an adipocyte-specific secretory protein encoded by the gene has a causal role in insulin resistance. Anti-diabetic drugs increase plasma adiponectin by a poorly understood, post-transcriptional mechanism enhancing insulin sensitivity....
9.
Khan D, Terenzi F, Liu G, Ghosh P, Ye F, Nguyen K, et al.
Nat Commun
. 2023 Jun;
14(1):3385.
PMID: 37296097
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termini with poorly understood...
10.
Khan K, Fox P
Bioessays
. 2023 Mar;
45(5):e2300024.
PMID: 36916749
Complexes of two or more proteins form many, if not most, of the intracellular "machines" that execute physical and chemical work, and transmit information. Complexes can form from stochastic post-translational...