Paul L Fox
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Explore the profile of Paul L Fox including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Lee E, Kim S, Hwang J, Jang S, Park S, Choi S, et al.
Nat Commun
. 2022 Oct;
13(1):6455.
PMID: 36309524
The AKT signaling pathway plays critical roles in the resolution of inflammation. However, the underlying mechanisms of anti-inflammatory regulation and signal coordination remain unclear. Here, we report that anti-inflammatory AKT...
12.
Vasu K, Khan D, Ramachandiran I, Blankenberg D, Fox P
NAR Genom Bioinform
. 2022 Oct;
4(4):lqac076.
PMID: 36267124
Transcriptional and post-transcriptional mechanisms diversify the proteome beyond gene number, while maintaining a sequence relationship between original and altered proteins. A new mechanism breaks this paradigm, generating novel proteins by...
13.
Khan K, Long B, Gogonea V, Deshpande G, Vasu K, Fox P
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2205669119.
PMID: 36037331
Amino acid ligation to cognate transfer RNAs (tRNAs) is catalyzed by aminoacyl-tRNA synthetases (aaRSs)-essential interpreters of the genetic code during translation. Mammalian cells harbor 20 cytoplasmic aaRSs, out of which...
14.
Chen X, Zhao J, Herjan T, Hong L, Liao Y, Liu C, et al.
J Exp Med
. 2022 Apr;
219(6).
PMID: 35389431
Increasing evidence suggests that intratumoral inflammation has an outsized influence on antitumor immunity. Here, we report that IL-17, a proinflammatory cytokine widely associated with poor prognosis in solid tumors, drives...
15.
Khan K, Baleanu-Gogonea C, Willard B, Gogonea V, Fox P
STAR Protoc
. 2022 Mar;
3(1):101201.
PMID: 35284842
Despite recent advances in structural determination of individual proteins, elucidating the 3-dimensional architecture of large, multiprotein complexes remains challenging, partly because of issues related to structural integrity during purification. Here,...
16.
Khan K, Gogonea V, Fox P
Transl Oncol
. 2022 Mar;
19:101392.
PMID: 35278792
In mammalian cells, 20 aminoacyl-tRNA synthetases (AARS) catalyze the ligation of amino acids to their cognate tRNAs to generate aminoacylated-tRNAs. In higher eukaryotes, 9 of the 20 AARSs, along with...
17.
Khan K, Long B, Baleanu-Gogonea C, Gogonea V, Deshpande G, Vasu K, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(7).
PMID: 35140182
Multiprotein assemblages are the intracellular workhorses of many physiological processes. Assembly of constituents into complexes can be driven by stochastic, domain-dependent, posttranslational events in which mature, folded proteins specifically interact....
18.
Vasu K, Fox P
STAR Protoc
. 2021 Sep;
2(4):100785.
PMID: 34585153
CRISPR-Cas9-mediated, site-directed mutagenesis in mice generates mosaic founder mice with varied efficiency of desired point mutation and other non-homologous end-joined variants. Here, we present a protocol for design, sample preparation,...
19.
Yao P, Fox P
Enzymes
. 2021 Apr;
48:243-275.
PMID: 33837706
Aminoacyl-tRNA synthetases (ARSs) are a family of essential "housekeeping" enzymes ubiquitous in the three major domains of life. ARSs uniquely connect the essential minimal units of both major oligomer classes-the...
20.
Vasu K, Ramachandiran I, Terenzi F, Khan D, China A, Khan K, et al.
iScience
. 2021 Mar;
24(3):102215.
PMID: 33748704
Aminoacyl-tRNA synthetases (AARS) participate in decoding the genome by catalyzing conjugation of amino acids to their cognate tRNAs. During evolution, biochemical and environmental conditions markedly influenced the sequence and structure...