Paul J Hertzog
Overview
Explore the profile of Paul J Hertzog including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
7750
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Recent Articles
1.
Tong D, He Y, Haile S, Lee Z, Le L, Emery J, et al.
Eur J Immunol
. 2024 Dec;
55(2):e202451355.
PMID: 39686777
Helicobacter infection is a key cause of gastric B cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell-activating factor (BAFF), a major driver of B...
2.
Al Qureshah F, Le Pen J, de Weerd N, Moncada-Velez M, Materna M, Lin D, et al.
J Exp Med
. 2024 Dec;
222(2).
PMID: 39680367
Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is...
3.
Wijayarathna R, de Geus E, Genovese R, Gearing L, Wray-McCann G, Sreenivasan R, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012702.
PMID: 39621805
The testis is a reservoir for viruses that can cause persistent infection and adversely affect male reproductive health, an observation commonly attributed to deficiencies in inducible antiviral defence mechanisms. In...
4.
Guanizo A, Luong Q, Jayasekara W, de Geus E, Inampudi C, Xue V, et al.
Nat Immunol
. 2024 Nov;
25(12):2259-2269.
PMID: 39572642
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an overall survival rate of ~5%. The transcription factor signal transducer and activator...
5.
Leibel S, McVicar R, Murad R, Kwong E, Clark A, Alvarado A, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(30):e2408109121.
PMID: 39028694
The prevalence of "long COVID" is just one of the conundrums highlighting how little we know about the lung's response to viral infection, particularly to syndromecoronavirus-2 (SARS-CoV-2), for which the...
6.
Fung K, de Geus E, Ying L, Cumming H, Bourke N, Foster S, et al.
Mol Cell Biol
. 2024 Jul;
44(8):334-343.
PMID: 38975675
Interferon epsilon (IFNε) is a unique type I interferon (IFN) that shows distinct constitutive expression in reproductive tract epithelium. Understanding how IFNε expression is regulated is critical for the mechanism...
7.
Mayall J, Horvat J, Mangan N, Chevalier A, McCarthy H, Hampsey D, et al.
EMBO Mol Med
. 2024 Jan;
16(2):267-293.
PMID: 38263527
The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in...
8.
de Geus E, Volaric J, Matthews A, Mangan N, Chang J, Ooi J, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Oct;
17(2):267-278.
PMID: 37879406
Background & Aims: Type I interferon (T1IFN) signalling is crucial for maintaining intestinal homeostasis. We previously found that the novel T1IFN, IFNε, is highly expressed by epithelial cells of the...
9.
Marks Z, Campbell N, Mangan N, Vandenberg C, Gearing L, Matthews A, et al.
Nature
. 2023 Aug;
620(7976):1063-1070.
PMID: 37587335
High-grade serous ovarian cancers have low survival rates because of their late presentation with extensive peritoneal metastases and frequent chemoresistance, and require new treatments guided by novel insights into pathogenesis....
10.
de Weerd N, Ogungbola O, Liu X, Matthews A, Ismail A, Vivian J, et al.
J Interferon Cytokine Res
. 2023 Jul;
43(9):403-413.
PMID: 37499093
Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also modulate immune responses by acting through a heterodimeric receptor composed of the specific and limited expressed IFN-λR1 chain...